PMID- 33072431
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2161-8674 (Print)
IS  - 2161-864X (Electronic)
IS  - 2161-864X (Linking)
VI  - 9
IP  - 3
DP  - 2020
TI  - Caffeine Intake During Pregnancy and Risk of Childhood Obesity: A Systematic 
      Review.
PG  - 364-380
LID - 10.21106/ijma.387 [doi]
AB  - OBJECTIVE: This paper evaluates the association between caffeine consumption 
      during pregnancy and overweight or obesity in the offspring. METHODS: Following 
      the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      guidelines, a literature search was conducted using MedLine, PubMed, CINAHL-Plus 
      and Google Scholar databases. Inclusion criteria were cohort studies on 
      participants with live singleton births at >/=28 weeks gestation who had consumed 
      caffeine during pregnancy. Included were studies reporting both measurement of 
      maternal caffeine intake and offspring anthropometric measurements. Studies 
      reporting serum paraxanthine, a measurement of caffeine intake, were also 
      included. RESULTS: After final elimination, there were eight studies meeting our 
      inclusion criteria. From these studies, we deduced that caffeine intake during 
      pregnancy between 50 mg and <150 mg/day was associated with increased risk of 
      overweight and obesity by excess fat deposition or increased weight, and elevated 
      BMI per International Obesity Task Force (IOTF) criteria using a reference 
      population. The majority of studies reported the strongest association with 
      maternal caffeine intake during pregnancy and overweight and obesity risk 
      beginning at >/=300 mg/day. CONCLUSIONS AND GLOBAL HEALTH IMPLICATION: The risk of 
      childhood overweight or obesity was associated with caffeine consumption at 50 
      mg/day during pregnancy with a stronger association at intakes >/=300 mg/day and 
      higher. The current recommendation of <200 mg/day of caffeine during pregnancy is 
      likely associated with lower risk of overweight or obesity in offspring but 
      avoidance of the substance is recommended.
CI  - Copyright (c) 2020 Frayer and Kim et al.
FAU - Frayer, Natalie C
AU  - Frayer NC
AD  - Nutrition and Dietetics Program, Central Michigan University, 1200 S. Franklin 
      St. Mount Pleasant, MI 48859, USA.
FAU - Kim, Yeonsoo
AU  - Kim Y
AD  - Nutrition and Dietetics Program, Central Michigan University, 207 Wightman Hall 
      1202 S. Washington St. Mount Pleasant, MI 48859, USA.
LA  - eng
PT  - Journal Article
DEP - 20200919
PL  - United States
TA  - Int J MCH AIDS
JT  - International journal of MCH and AIDS
JID - 101677679
PMC - PMC7545400
OTO - NOTNLM
OT  - Caffeine intake
OT  - Childhood
OT  - Obesity
OT  - Overweight
OT  - Pregnancy
OT  - Prenatal
OT  - Serum paraxanthine
OT  - Systematic review
COIS- Conflicts of Interest: The authors declare no conflicts of interest.
EDAT- 2020/10/20 06:00
MHDA- 2020/10/20 06:01
PMCR- 2020/09/19
CRDT- 2020/10/19 05:57
PHST- 2020/10/19 05:57 [entrez]
PHST- 2020/10/20 06:00 [pubmed]
PHST- 2020/10/20 06:01 [medline]
PHST- 2020/09/19 00:00 [pmc-release]
AID - IJMA-9-364 [pii]
AID - 10.21106/ijma.387 [doi]
PST - ppublish
SO  - Int J MCH AIDS. 2020;9(3):364-380. doi: 10.21106/ijma.387. Epub 2020 Sep 19.