PMID- 33072898
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2405-6731 (Electronic)
IS  - 2405-6731 (Linking)
VI  - 11
DP  - 2020 Nov
TI  - Clinical, serological and DNA testing in Bengo Province, Angola further reveals 
      low filarial endemicity and opportunities for disease elimination.
PG  - e00183
LID - 10.1016/j.parepi.2020.e00183 [doi]
LID - e00183
AB  - The prevalence of Loa loa, Onchocerca volvulus and Wuchereria bancrofti 
      infections in an under-surveyed area of Bengo Province, Angola, was determined by 
      surveying 22 communities with a combination of clinical, serological and DNA 
      diagnostics. Additional information was collected on participants' duration of 
      residency, access to mass drug administration, knowledge of insect vectors and 
      use of bednets. A total of 1616 individuals (38.1% male: 61.9% female), with an 
      average age of 43 years, were examined. For L. loa, 6.2% (n = 100/16616) 
      individuals were found to have eyeworm, based on the rapid assessment procedure 
      for loiasis (RAPLOA) surveys, and 11.5% (n =178/1543) based on nested PCR 
      analyses of venous blood. L. loa prevalences in long-term residents (>10 years) 
      and older individuals (>60 years) were significantly higher, and older men with 
      eyeworm were better informed about Chrysops vectors. For O. volvulus, 4.7% 
      (n = 74/1567) individuals were found to be positive by enzyme-linked 
      immunosorbent assay (Ov 16 ELISA), with only three individuals reporting to have 
      ever taken ivermectin. For W. bancrofti, no infections were found using the 
      antigen-based immunochromatographic test (ICT) and real-time PCR analysis; 
      however, 27 individuals presented with lymphatic filariasis (LF) related clinical 
      conditions (lymphoedema = 11, hydrocoele = 14, both = 2). Just under half (45.5%) 
      of the participants owned a bednet, with the majority (71.1%) sleeping under it 
      the night before. Our approach of using combination diagnostics reveals the 
      age-prevalence of loiasis alongside low endemicity of onchocerciasis and LF. 
      Future research foci should be on identifying opportunities for more 
      cost-effective ways to eliminate onchocerciasis and to develop innovative 
      surveillance modalities for clinical LF for individual disease management and 
      disability prevention.
CI  - (c) 2020 The Authors.
FAU - Paulo, Rossely
AU  - Paulo R
AD  - Centro de Investigacao em Saude de Angola(CISA)/Health Research Centre of Angola, 
      Caxito, Angola.
AD  - Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, 
      Liverpool, UK.
FAU - Brito, Miguel
AU  - Brito M
AD  - Centro de Investigacao em Saude de Angola(CISA)/Health Research Centre of Angola, 
      Caxito, Angola.
AD  - Health and Technology Research Center (H&TRC), Escola Superior de Tecnologia da 
      Saude de Lisboa, Instituto Politecnico de Lisboa, Portugal.
FAU - Van-Dunem, Pedro
AU  - Van-Dunem P
AD  - National Directorate of Public Health, Ministry of Health, Angola.
FAU - Martins, Antonio
AU  - Martins A
AD  - Centro de Investigacao em Saude de Angola(CISA)/Health Research Centre of Angola, 
      Caxito, Angola.
FAU - Novak, Robert J
AU  - Novak RJ
AD  - College of Public Health, University of South Florida, Florida, USA.
FAU - Jacob, Benjamin
AU  - Jacob B
AD  - College of Public Health, University of South Florida, Florida, USA.
FAU - Molyneux, David M
AU  - Molyneux DM
AD  - Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, 
      Liverpool, UK.
FAU - Unnasch, Thomas R
AU  - Unnasch TR
AD  - College of Public Health, University of South Florida, Florida, USA.
FAU - Stothard, J Russell
AU  - Stothard JR
AD  - Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, 
      Liverpool, UK.
FAU - Kelly-Hope, Louise
AU  - Kelly-Hope L
AD  - Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, 
      Liverpool, UK.
LA  - eng
PT  - Journal Article
DEP - 20200923
PL  - Netherlands
TA  - Parasite Epidemiol Control
JT  - Parasite epidemiology and control
JID - 101687137
PMC - PMC7548300
OTO - NOTNLM
OT  - Chrysops
OT  - Co-infection
OT  - Loiasis
OT  - Lymphatic filariasis
OT  - Mapping
OT  - Onchocerciasis
COIS- The authors declare that they have no competing interest.
EDAT- 2020/10/20 06:00
MHDA- 2020/10/20 06:01
PMCR- 2020/09/23
CRDT- 2020/10/19 05:59
PHST- 2020/06/16 00:00 [received]
PHST- 2020/07/31 00:00 [revised]
PHST- 2020/09/20 00:00 [accepted]
PHST- 2020/10/19 05:59 [entrez]
PHST- 2020/10/20 06:00 [pubmed]
PHST- 2020/10/20 06:01 [medline]
PHST- 2020/09/23 00:00 [pmc-release]
AID - S2405-6731(20)30052-0 [pii]
AID - e00183 [pii]
AID - 10.1016/j.parepi.2020.e00183 [doi]
PST - epublish
SO  - Parasite Epidemiol Control. 2020 Sep 23;11:e00183. doi: 
      10.1016/j.parepi.2020.e00183. eCollection 2020 Nov.