PMID- 33073940
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 66
IP  - 10
DP  - 2020 Oct 1
TI  - Risk Interval of Complete Blood Counts May be Closely Associated with Bone 
      Mineral Density in the Elderly Chinese Population.
LID - 10.7754/Clin.Lab.2020.191238 [doi]
AB  - BACKGROUND: Accumulating research suggests that hematopoiesis and bone metabolism 
      are interconnected. Several studies have investigated the partial indexes of 
      peripheral blood counts related to bone mineral density (BMD). The aim of this 
      study was to investigate the associations between all of the parameters, 
      especially the risk interval of complete blood counts (CBC) and BMD in a sample 
      of elderly subjects aged >70 years. METHODS: Three hundred and eighty-six 
      subjects aged > 70 years in our hospital were enrolled in a cross-sectional study 
      and underwent BMD measurement along with a CBC test. Patients were divided into 
      two groups: "at least osteopenia" (T-score < -1) and a normal group (T-score >/= 
      -1). The clinicopathological characteristics, CBC parameters, and BMD were 
      analyzed between the two groups. We performed a supervised discretization (using 
      a conditional inference tree algorithm) to find the risk interval for the 
      continuous variables, especially for CBC parameters, and bootstrap multivariable 
      logistic regression to estimate the odds of CBC parameters associated with BMD. 
      RESULTS: A total of 248 subjects were included in the study and divided into the 
      normal (n = 43) and "at least osteopenia" groups (n = 205). Subjects in the "at 
      least osteopenia" group had varying degrees of decreases in white blood cell 
      (WBC) count, red blood cell (RBC) count, hemoglobin (Hb), mean corpuscular 
      hemoglobin concentration (MCHC), hematocrit (HCT), platelet volume distribution 
      width (PDW) mean platelet volume (MPV), eosinophils, and lymphocytes, and had 
      increases in platelets (PLTs). MCHC, WBC, RBC, PDW, MPV, Hb, and lymphocytes were 
      successfully divided into two (low and high) intervals. Bootstrap logistic 
      regression showed that low levels of body mass index (BMI) [(11.88, 23.53); OR: 
      4.07; p < 0.0001], lymphocytes [(0.54, 2.3); OR: 3.95; p < 0.0001] and PDW [(8.5, 
      12.7); OR: 2.44; p < 0.0001] along with being female and older age [(72, 97); OR: 
      2.16; p < 0.0001] were significantly associated with BMD as risk factors. 
      CONCLUSIONS: The elderly with BMD loss tended to show an abnormal sign in the CBC 
      test. Low levels of lymphocytes and PDW may contribute to the evaluation of 
      osteoporosis risk in the elderly. Bone remodeling and hematopoiesis may have 
      stronger associations and interactions than has been previously recognized.
FAU - Ou-Yang, Jing
AU  - Ou-Yang J
FAU - Zhang, Jinhe
AU  - Zhang J
FAU - Tan, Xin
AU  - Tan X
FAU - Su, Hairong
AU  - Su H
FAU - Dai, Jie
AU  - Dai J
FAU - Li, Juanmin
AU  - Li J
FAU - Ou, Aihua
AU  - Ou A
FAU - Liang, Likeng
AU  - Liang L
FAU - Deng, Weimin
AU  - Deng W
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
SB  - IM
MH  - Aged
MH  - Blood Cell Count
MH  - *Bone Density
MH  - *Bone Diseases, Metabolic/diagnostic imaging
MH  - China
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
EDAT- 2020/10/20 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/19 09:42
PHST- 2020/10/19 09:42 [entrez]
PHST- 2020/10/20 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
AID - 10.7754/Clin.Lab.2020.191238 [doi]
PST - ppublish
SO  - Clin Lab. 2020 Oct 1;66(10). doi: 10.7754/Clin.Lab.2020.191238.