PMID- 33074172
OWN - NLM
STAT- MEDLINE
DCOM- 20210917
LR  - 20221005
IS  - 1848-6312 (Electronic)
IS  - 0004-1254 (Print)
IS  - 0004-1254 (Linking)
VI  - 71
IP  - 3
DP  - 2020 Sep 1
TI  - Redox and essential metal status in the brain of Wistar rats acutely exposed to a 
      cadmium and lead mixture.
PG  - 197-204
LID - 10.2478/aiht-2020-71-3425 [doi]
AB  - Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic 
      metals alone, while data on co-exposure are scarce. The aim of our study was to 
      fill that gap by investigating acute combined effects of Pb and Cd on redox and 
      essential metal status in the brain of Wistar rats. Animals were randomised in 
      four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg 
      of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group 
      received distilled water only. Co-treatment with Pb and Cd induced significant 
      increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances 
      (TBARS) compared to control and groups receiving either metal alone. This is of 
      special importance, as MDA presence in the brain has been implicated in many 
      neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, 
      Mn, and Fe brain levels. Our findings highlight the importance of metal mixture 
      studies. Neurotoxicity assessments of single chemicals do not provide a real 
      insight into exposure to mixtures in real life. Further research should look into 
      interactions between these metals to reveal complex molecular mechanisms of their 
      neurotoxicity.
FAU - Javorac, Dragana
AU  - Javorac D
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Dordevic, Aleksandra Buha
AU  - Dordevic AB
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Andelkovic, Milena
AU  - Andelkovic M
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
AD  - Health Centre Kosovska Mitrovica, Kosovska Mitrovica, Serbia.
FAU - Tatovic, Simona
AU  - Tatovic S
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Baralic, Katarina
AU  - Baralic K
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Antonijevic, Evica
AU  - Antonijevic E
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Kotur-Stevuljevic, Jelena
AU  - Kotur-Stevuljevic J
AD  - University of Belgrade Faculty of Pharmacy, Department of Biochemistry, Belgrade, 
      Serbia.
FAU - Dukic-Cosic, Danijela
AU  - Dukic-Cosic D
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Antonijevic, Biljana
AU  - Antonijevic B
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
FAU - Bulat, Zorica
AU  - Bulat Z
AD  - University of Belgrade Faculty of Pharmacy, Department of Toxicology "Akademik 
      Danilo Soldatovic", Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20201006
PL  - Croatia
TA  - Arh Hig Rada Toksikol
JT  - Arhiv za higijenu rada i toksikologiju
JID - 0373100
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Animals
MH  - Brain
MH  - *Cadmium/toxicity
MH  - *Lead/toxicity
MH  - Oxidation-Reduction
MH  - Rats
MH  - Rats, Wistar
PMC - PMC7968497
OTO - NOTNLM
OT  - Cd
OT  - Cu
OT  - Fe
OT  - MDA
OT  - Mn
OT  - Pb
OT  - TBARS
OT  - Zn
OT  - neurotoxicity
OT  - oxidative stress
COIS- Conflicts of interest None to declare.
EDAT- 2020/10/20 06:00
MHDA- 2021/09/18 06:00
PMCR- 2020/10/06
CRDT- 2020/10/19 12:23
PHST- 2020/04/01 00:00 [received]
PHST- 2020/09/01 00:00 [accepted]
PHST- 2020/10/19 12:23 [entrez]
PHST- 2020/10/20 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/10/06 00:00 [pmc-release]
AID - aiht-2020-71-3425 [pii]
AID - 10.2478/aiht-2020-71-3425 [doi]
PST - epublish
SO  - Arh Hig Rada Toksikol. 2020 Oct 6;71(3):197-204. doi: 10.2478/aiht-2020-71-3425. 
      Print 2020 Sep 1.