PMID- 33074586 OWN - NLM STAT- Publisher LR - 20240222 IS - 1753-0407 (Electronic) IS - 1753-0407 (Linking) DP - 2020 Oct 19 TI - Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China. LID - 10.1111/1753-0407.13123 [doi] AB - BACKGROUND: The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory. METHODS: A total of 18 444 participants aged 18-80 years old were included in this cohort study. Linear regression and quadratic regression models were used to determine the TG/HDL-C ratio change trajectory. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TG/HDL-C ratio change trajectory and probability of T2DM. RESULTS: T2DM developed in 714 participants during a median follow-up of 5.74 years (92 076.23 person-years of follow-up). After adjusting for baseline potential confounders, odds of T2DM were greater for participants with the increasing, U-shape, bell-shape, and other shape change vs decreasing change (adjusted OR [aOR] 2.01, 95% CI 1.42-2.81; 1.56, 1.15-2.13; 1.60, 1.17-2.20; and 1.49, 1.13-2.00, respectively). The results were robust in the sensitivity analyses on excluding baseline participants with T2DM. Moreover, the associations remained significant with male sex, age <60 years and body mass index <24 kg/m(2) . CONCLUSIONS: This retrospective study revealed increased probability of T2DM with increasing, U-shape, bell-shape, and other-shape TG/HDL-C ratio change trajectories, especially with male sex, age <60 years and body mass index <24 kg/m(2) . CI - (c) 2020 Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd. FAU - Zhang, Yanyan AU - Zhang Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Qin, Pei AU - Qin P AUID- ORCID: 0000-0003-2303-0379 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Lou, Yanmei AU - Lou Y AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China. FAU - Zhao, Ping AU - Zhao P AD - Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China. FAU - Li, Xue AU - Li X AD - Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, People's Republic of China. FAU - Qie, Ranran AU - Qie R AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Wu, Xiaoyan AU - Wu X AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Han, Minghui AU - Han M AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Huang, Shengbing AU - Huang S AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Liu, Dechen AU - Liu D AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Wu, Yuying AU - Wu Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Li, Yang AU - Li Y AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Yang, Xingjin AU - Yang X AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Zhao, Yang AU - Zhao Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Feng, Yifei AU - Feng Y AD - Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China. FAU - Wang, Changyi AU - Wang C AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Ma, Jianping AU - Ma J AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Peng, Xiaolin AU - Peng X AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Chen, Hongen AU - Chen H AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Zhao, Dan AU - Zhao D AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Xu, Shan AU - Xu S AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Wang, Li AU - Wang L AD - Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China. FAU - Luo, Xinping AU - Luo X AD - School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Zhang, Ming AU - Zhang M AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Hu, Dongsheng AU - Hu D AUID- ORCID: 0000-0002-9998-8041 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. FAU - Hu, Fulan AU - Hu F AUID- ORCID: 0000-0002-2386-1503 AD - Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China. LA - eng GR - A2017181/Medical Research Foundation of Guangdong Province/ GR - 2017057/Nanshan Science and Technology Innovation Bureau/ GR - 81373074/National Natural Science Foundation of China/ GR - 81402752/National Natural Science Foundation of China/ GR - 81673260/National Natural Science Foundation of China/ GR - 2017A030313452/Natural Science Foundation of Guangdong Province/ GR - Sanming Project of Medicine in NanShan district/ GR - SZSM201803080/Sanming Project of Medicine in Shenzhen/ GR - CYJ20140418091413562/Science and Technology Development Foundation of Shenzhen/ GR - JCYJ20160307155707264/Science and Technology Development Foundation of Shenzhen/ GR - JCYJ2/Science and Technology Development Foundation of Shenzhen/ PT - Journal Article DEP - 20201019 PL - Australia TA - J Diabetes JT - Journal of diabetes JID - 101504326 SB - IM OTO - NOTNLM OT - TG/HDL-C ratio OT - change trajectory OT - type 2 diabetes mellitus EDAT- 2020/10/20 06:00 MHDA- 2020/10/20 06:00 CRDT- 2020/10/19 12:25 PHST- 2020/07/23 00:00 [received] PHST- 2020/09/20 00:00 [revised] PHST- 2020/10/15 00:00 [accepted] PHST- 2020/10/20 06:00 [pubmed] PHST- 2020/10/20 06:00 [medline] PHST- 2020/10/19 12:25 [entrez] AID - 10.1111/1753-0407.13123 [doi] PST - aheadofprint SO - J Diabetes. 2020 Oct 19. doi: 10.1111/1753-0407.13123.