PMID- 33075217 OWN - NLM STAT- MEDLINE DCOM- 20210614 LR - 20210614 IS - 1532-0987 (Electronic) IS - 0891-3668 (Linking) VI - 39 IP - 11 DP - 2020 Nov TI - Epidemiology of Kawasaki Disease in South Korea: A Nationwide Survey 2015-2017. PG - 1012-1016 LID - 10.1097/INF.0000000000002793 [doi] AB - BACKGROUND: This study aimed to investigate recent epidemiologic features of Kawasaki disease (KD) in South Korea. METHODS: The ninth triennial nationwide questionnaire survey collected data on the demographic findings, symptoms and signs, treatment patterns and coronary artery complications of acute-phase KD occurred in 2015-2017 from 98 hospitals with pediatric residency programs and 108 community hospitals without residency programs. RESULTS: We received data from 93 of the 98 hospitals (response rate: 94.9%) with residency programs and 75 of the 108 community-based children's hospitals (response rate: 69.4%) without residency programs. In the 3-year survey period, a total of 15,378 (5449 in 2015, 5171 in 2016 and 4758 in 2017) cases of KD were reported. The mean age at diagnosis was 33.0 +/- 24.8 months (range: 0-205 months), and the male-to-female ratio was 1.41:1. The overall KD incidence was 196.9 (202.2 in 2015, 197.1 in 2016 and 191.0 in 2017) per 100,000 younger than 5 years population. Recurrent cases were 4.85%. KD occurred more frequently during winter (December-January) and late spring (May-June). Intravenous immunoglobulin (IVIG) was administered to 95% of the patients; nonresponder rate for the first IVIG was 14.8%. Coronary artery aneurysms and giant coronary artery aneurysms (internal diameter >8 mm) occurred in 1.7% and 19 patients, respectively. Two patients died due to multiorgan failure and hepatic encephalopathy. CONCLUSION: Peak incidence of KD in South Korea was 202.2 per 100,000 younger than 5 years population (2015), and the incidence of giant coronary artery aneurysm decreased to 0.09% (2017). FAU - Kim, Gi Beom AU - Kim GB AD - From the Department of Pediatrics, Seoul National University Children's Hospital, Seoul. FAU - Eun, Lucy Youngmin AU - Eun LY AD - Department of Pediatrics, Yonsei University Severance Hospital, Seoul. FAU - Han, Ji Whan AU - Han JW AD - Department of Pediatrics, The Catholic University of Korea, Seoul, South Korea. FAU - Kim, Sung Hye AU - Kim SH AD - Department of Pediatrics, CHA Bundang Medical Center, Gyeonggi-do, South Korea. FAU - Yoon, Kyung Lim AU - Yoon KL AD - Department of Pediatrics, Kyung Hee University Hospital, Seoul, South Korea. FAU - Han, Mi Young AU - Han MY AD - Department of Pediatrics, Asan Medical Center, Seoul, South Korea. FAU - Yu, Jeong Jin AU - Yu JJ AD - Department of Pediatrics, Asan Medical Center, Seoul, South Korea. FAU - Choi, Jong-Woon AU - Choi JW AD - Department of Pediatrics, Bundang Jesaeng General Hospital, Gyeonggi-do, South Korea. FAU - Rhim, Jung Woo AU - Rhim JW AD - Department of Pediatrics, The Catholic University of Korea, Daejeon, South Korea. LA - eng PT - Journal Article PL - United States TA - Pediatr Infect Dis J JT - The Pediatric infectious disease journal JID - 8701858 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Coronary Aneurysm/epidemiology/etiology MH - Female MH - Humans MH - Immunoglobulins, Intravenous/therapeutic use MH - Incidence MH - Infant MH - Infant, Newborn MH - Male MH - Mucocutaneous Lymph Node Syndrome/complications/drug therapy/*epidemiology MH - Republic of Korea/epidemiology MH - Surveys and Questionnaires EDAT- 2020/10/20 06:00 MHDA- 2021/06/16 06:00 CRDT- 2020/10/19 17:37 PHST- 2020/10/19 17:37 [entrez] PHST- 2020/10/20 06:00 [pubmed] PHST- 2021/06/16 06:00 [medline] AID - 00006454-202011000-00011 [pii] AID - 10.1097/INF.0000000000002793 [doi] PST - ppublish SO - Pediatr Infect Dis J. 2020 Nov;39(11):1012-1016. doi: 10.1097/INF.0000000000002793.