PMID- 33076391
OWN - NLM
STAT- MEDLINE
DCOM- 20210226
LR  - 20210226
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 12
IP  - 10
DP  - 2020 Oct 15
TI  - An Outbreak of a Respiratory Disorder at a Russian Swine Farm Associated with the 
      Co-Circulation of PRRSV1 and PRRSV2.
LID - 10.3390/v12101169 [doi]
LID - 1169
AB  - We conducted a cross-sectional study to identify the major respiratory pathogen 
      responsible for an outbreak of respiratory disease at a swine farm in West 
      Siberia in 2019. We discovered that the peak of morbidity and mortality coincided 
      with a high level of porcine reproductive and respiratory syndrome virus (PRRSV) 
      1 and 2-related viremia. Based on longer PRRSV2 viremia, the dominant role of 
      PRRSV2 over PRRSV1 in the outbreak was assumed. Phylogenetic analysis revealed 
      that the PRRSV1 strain belonged to sub-genotype 2-one of the predominant groups 
      of genotype 1 PRRSVs in Russia. A partial open reading frame 7 sequence of the 
      PRRSV2 isolate demonstrated a high identity with modified live vaccine-related 
      strains from Denmark (93%) and wild-type VR2332 (92%). We identified the first 
      instance of PRRSV1/PRRSV2 mixed infection in Russia. This finding indicates that 
      further field investigations are needed to access PRRSV2 epidemiology in eastern 
      Europe.
FAU - Raev, Sergei
AU  - Raev S
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
FAU - Yuzhakov, Anton
AU  - Yuzhakov A
AUID- ORCID: 0000-0002-0426-9678
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
FAU - Bulgakov, Alexandr
AU  - Bulgakov A
AUID- ORCID: 0000-0002-8405-8562
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
FAU - Kostina, Ludmila
AU  - Kostina L
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
FAU - Gerasianinov, Alexei
AU  - Gerasianinov A
AD  - Siberian Agrarian Group, 634009 Tomsk, Russia.
FAU - Verkhovsky, Oleg
AU  - Verkhovsky O
AD  - Laboratory of Virology, Diagnostics and Prevention Research Institute for Human 
      and Animal Diseases, 123098 Moscow, Russia.
FAU - Zaberezhny, Alexei
AU  - Zaberezhny A
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
FAU - Aliper, Taras
AU  - Aliper T
AD  - Federal State Budget Scientific Institution "Federal Scientific Center VIEV", 
      109428 Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201015
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Cross-Sectional Studies
MH  - Disease Outbreaks/*veterinary
MH  - Farms
MH  - Genetic Variation
MH  - Genotype
MH  - Open Reading Frames
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/*epidemiology/mortality/virology
MH  - Porcine respiratory and reproductive syndrome virus/classification/*pathogenicity
MH  - Siberia/epidemiology
MH  - Swine/virology
PMC - PMC7602620
OTO - NOTNLM
OT  - ORF7
OT  - PCV2
OT  - PRRSV1
OT  - PRRSV2
OT  - antibody detection
OT  - cross-sectional
OT  - phylogenetic analysis
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/21 06:00
MHDA- 2021/02/27 06:00
PMCR- 2020/10/01
CRDT- 2020/10/20 01:03
PHST- 2020/09/20 00:00 [received]
PHST- 2020/10/06 00:00 [revised]
PHST- 2020/10/11 00:00 [accepted]
PHST- 2020/10/20 01:03 [entrez]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/02/27 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - v12101169 [pii]
AID - viruses-12-01169 [pii]
AID - 10.3390/v12101169 [doi]
PST - epublish
SO  - Viruses. 2020 Oct 15;12(10):1169. doi: 10.3390/v12101169.