PMID- 330767
OWN - NLM
STAT- MEDLINE
DCOM- 19771020
LR  - 20190509
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 136
IP  - 2
DP  - 1977 Aug
TI  - Relative enterotoxigenicity of coliform bacteria.
PG  - 205-15
AB  - The enterotoxigenicity of 12 strains of coliform bacteria (Enterobacter cloacae, 
      Klebsiella pneumoniae, and Escherichia coli) isolated from the gastrointestinal 
      (GI) tract of persons with either acute diarrhea or tropical sprue and of 13 
      strains of the same species isolated from urine (GU) cultures was determined. 
      Fractions of heat-labile (LT) and heat-stable (ST) toxins of each strain were 
      separated by ultrafiltration, and the effect of graded concentrations (range, 100 
      microgram-10 pg/ml) on water transport was assessed by in vivo perfusion in the 
      rat jejunum. Enterotoxigenic activity was defined as inducement of net secretion 
      of water. All 12 of the GI strains and six of 13 GU strains elaborated 
      enterotoxins, but there was a millionfold quantitative difference in the potency 
      of the toxins produced. All of the GI strains produced one or both forms of 
      toxin, which had a minimal effective concentration of as low as 0.1-10 ng/ml, 
      whereas the GU strains produced toxins of weak or, rarely, of intermediate 
      potency.
FAU - Klipstein, F A
AU  - Klipstein FA
FAU - Engert, R F
AU  - Engert RF
FAU - Short, H B
AU  - Short HB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Enterotoxins)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Biological Assay
MH  - Enterobacteriaceae/*analysis
MH  - Enterotoxins/*analysis/pharmacology
MH  - Escherichia coli/*analysis
MH  - Hot Temperature
MH  - Jejunum/drug effects
MH  - Klebsiella pneumoniae/*analysis
MH  - Male
MH  - Rats
MH  - Species Specificity
MH  - Water/metabolism
EDAT- 1977/08/01 00:00
MHDA- 1977/08/01 00:01
CRDT- 1977/08/01 00:00
PHST- 1977/08/01 00:00 [pubmed]
PHST- 1977/08/01 00:01 [medline]
PHST- 1977/08/01 00:00 [entrez]
AID - 10.1093/infdis/136.2.205 [doi]
PST - ppublish
SO  - J Infect Dis. 1977 Aug;136(2):205-15. doi: 10.1093/infdis/136.2.205.