PMID- 33078236
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20220419
IS  - 1432-086X (Electronic)
IS  - 0174-1551 (Linking)
VI  - 44
IP  - 2
DP  - 2021 Feb
TI  - Systematic Review and Meta-analysis Comparing Prostatic Artery Embolization to 
      Gold-Standard Transurethral Resection of the Prostate for Benign Prostatic 
      Hyperplasia.
PG  - 183-193
LID - 10.1007/s00270-020-02657-5 [doi]
AB  - PURPOSE: To report a comparative systematic review and meta-analysis of prostatic 
      artery embolization (PAE) and transurethral resection of the prostate (TURP) for 
      the management of benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: A 
      multi-database search for relevant literature was conducted on 15 July 2020 to 
      include studies published on or before that date. Search terms used were: 
      (prostate embolization OR prostatic embolization OR prostate embolization OR 
      prostatic embolization) AND (prostatic hyperplasia OR prostatic obstruction). 
      Risk of bias was assessed using Cochrane Collaboration and ROBINS-I criteria. 
      Random-effects meta-analysis was performed using RevMan 5.3. RESULTS: Six studies 
      with 598 patients were included. TURP was associated with significantly more 
      improvement in maximum urinary flow rate (Q(max)) (mean difference = 5.02 mL/s; 
      95% CI [2.66,7.38]; p < 0.0001; I(2) = 89%), prostate volume (mean 
      difference = 15.59 mL; 95% CI [7.93,23.25]; p < 0.00001; I(2) = 88%), and 
      prostate-specific antigen (PSA) (mean difference = 1.02 ng/mL; 95% CI 
      [0.14,1.89]; p = 0.02; I(2) = 71%) compared to PAE. No significant difference 
      between PAE and TURP was observed for changes in International Prostate Symptoms 
      Score (IPSS), IPSS quality of life (IPSS-QoL), International Index of Erectile 
      Function (IIEF-5), and post-void residual (PVR). PAE was associated with fewer 
      adverse events (AEs) (39.0% vs. 77.7%; p < 0.00001) and shorter hospitalization 
      times (mean difference = -1.94 days; p < 0.00001), but longer procedural times 
      (mean difference = 51.43 min; p = 0.004). CONCLUSION: Subjective symptom 
      improvement was equivalent between TURP and PAE. While TURP demonstrated larger 
      improvements for some objective parameters, PAE was associated with fewer AEs and 
      shorter hospitalization times. LEVEL OF EVIDENCE II: Level 2a, Systematic Review.
FAU - Knight, Gabriel M
AU  - Knight GM
AD  - Department of Radiology, Section of Interventional Radiology, Northwestern 
      University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
FAU - Talwar, Abhinav
AU  - Talwar A
AD  - Department of Radiology, Section of Interventional Radiology, Northwestern 
      University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
FAU - Salem, Riad
AU  - Salem R
AUID- ORCID: 0000-0001-9745-1825
AD  - Department of Radiology, Section of Interventional Radiology, Northwestern 
      University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA. 
      r-salem@northwestern.edu.
AD  - Department of Medicine, Division of Hematology and Oncology, Northwestern 
      University, Chicago, IL, USA. r-salem@northwestern.edu.
FAU - Mouli, Samdeep
AU  - Mouli S
AD  - Department of Radiology, Section of Interventional Radiology, Northwestern 
      University, 676 N. St. Clair, Suite 800, Chicago, IL, 60611, USA.
AD  - Department of Medicine, Division of Hematology and Oncology, Northwestern 
      University, Chicago, IL, USA.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20201019
PL  - United States
TA  - Cardiovasc Intervent Radiol
JT  - Cardiovascular and interventional radiology
JID - 8003538
SB  - IM
CIN - Cardiovasc Intervent Radiol. 2021 Feb;44(2):194-195. PMID: 33205291
MH  - Aged
MH  - Arteries
MH  - Embolization, Therapeutic/*methods
MH  - Humans
MH  - Male
MH  - Prostate/*blood supply/surgery
MH  - Prostatic Hyperplasia/surgery/*therapy
MH  - Reference Standards
MH  - Transurethral Resection of Prostate/*methods
MH  - Treatment Outcome
EDAT- 2020/10/21 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/10/20 06:25
PHST- 2020/01/04 00:00 [received]
PHST- 2020/09/18 00:00 [accepted]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/10/20 06:25 [entrez]
AID - 10.1007/s00270-020-02657-5 [pii]
AID - 10.1007/s00270-020-02657-5 [doi]
PST - ppublish
SO  - Cardiovasc Intervent Radiol. 2021 Feb;44(2):183-193. doi: 
      10.1007/s00270-020-02657-5. Epub 2020 Oct 19.