PMID- 33078409
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20211206
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 61
IP  - 12
DP  - 2020 Dec
TI  - Focal nonmotor versus motor seizures: The impact on diagnostic delay in focal 
      epilepsy.
PG  - 2643-2652
LID - 10.1111/epi.16707 [doi]
AB  - OBJECTIVE: To test the hypothesis that people with focal epilepsy experience 
      diagnostic delays that may be associated with preventable morbidity, particularly 
      when seizures have only nonmotor symptoms, we compared time to diagnosis, 
      injuries, and motor vehicle accidents (MVAs) in people with focal nonmotor versus 
      focal seizures with motor involvement at epilepsy onset. METHODS: This 
      retrospective study analyzed the enrollment data from the Human Epilepsy Project, 
      which enrolled participants between 2012 and 2017 across 34 sites in the USA, 
      Canada, Europe, and Australia, within 4 months of treatment for focal epilepsy. A 
      total of 447 participants were grouped by initial seizure semiology (focal 
      nonmotor or focal with motor involvement) to compare time to diagnosis and 
      prediagnostic injuries including MVAs. RESULTS: Demographic characteristics were 
      similar between groups. There were 246 participants (55%) with nonmotor seizures 
      and 201 participants (45%) with motor seizures at epilepsy onset. Median time to 
      diagnosis from first seizure was 10 times longer in patients with nonmotor 
      seizures compared to motor seizures at onset (P < .001). The number and severity 
      of injuries were similar between groups. However, 82.6% of MVAs occurred in 
      patients with undiagnosed nonmotor seizures. SIGNIFICANCE: This study identifies 
      reasons for delayed diagnosis and consequences of delay in patients with new 
      onset focal epilepsy, highlighting a treatment gap that is particularly 
      significant in patients who experience nonmotor seizures at epilepsy onset.
CI  - (c) 2020 International League Against Epilepsy.
FAU - Pellinen, Jacob
AU  - Pellinen J
AUID- ORCID: 0000-0002-0747-7210
AD  - Department of Neurology, New York University Grossman School of Medicine and NYU 
      Langone Health, New York, NY, USA.
FAU - Tafuro, Erica
AU  - Tafuro E
AD  - Montefiore Medical Center, Bronx, NY, USA.
FAU - Yang, Annie
AU  - Yang A
AD  - Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
FAU - Price, Dana
AU  - Price D
AD  - Department of Neurology, New York University Grossman School of Medicine and NYU 
      Langone Health, New York, NY, USA.
FAU - Friedman, Daniel
AU  - Friedman D
AUID- ORCID: 0000-0003-1068-1797
AD  - Department of Neurology, New York University Grossman School of Medicine and NYU 
      Langone Health, New York, NY, USA.
FAU - Holmes, Manisha
AU  - Holmes M
AUID- ORCID: 0000-0002-4262-0764
AD  - Department of Neurology, New York University Grossman School of Medicine and NYU 
      Langone Health, New York, NY, USA.
FAU - Barnard, Sarah
AU  - Barnard S
AD  - Monash University School of Medicine, Clayton, Victoria, Australia.
FAU - Detyniecki, Kamil
AU  - Detyniecki K
AD  - Department of Neurology, University of Miami Miller School of Medicine, Miami, 
      FL, USA.
FAU - Hegde, Manu
AU  - Hegde M
AD  - Department of Neurology, University of California, San Francisco School of 
      Medicine, San Francisco, CA, USA.
FAU - Hixson, John
AU  - Hixson J
AD  - Department of Neurology, University of California, San Francisco School of 
      Medicine, San Francisco, CA, USA.
FAU - Haut, Sheryl
AU  - Haut S
AD  - Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Kalviainen, Reetta
AU  - Kalviainen R
AD  - Institute of Clinical Medicine, Kuopio University Hospital and University of 
      Eastern Finland, Kuopio, Finland.
FAU - French, Jacqueline
AU  - French J
AUID- ORCID: 0000-0003-2242-8027
AD  - Department of Neurology, New York University Grossman School of Medicine and NYU 
      Langone Health, New York, NY, USA.
CN  - Human Epilepsy Project Co-Investigators
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201019
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
CIN - Epilepsy Curr. 2021 Feb 16;21(3):173-174. PMID: 34867097
MH  - Adult
MH  - Delayed Diagnosis
MH  - Epilepsies, Partial/*diagnosis
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Seizures/*diagnosis/physiopathology
MH  - Time Factors
OTO - NOTNLM
OT  - clinical neurology
OT  - complex partial seizures
OT  - epilepsy semiology
OT  - epilepsy/seizures
OT  - partial seizures
EDAT- 2020/10/21 06:00
MHDA- 2021/03/04 06:00
CRDT- 2020/10/20 06:27
PHST- 2020/07/27 00:00 [received]
PHST- 2020/09/07 00:00 [revised]
PHST- 2020/09/07 00:00 [accepted]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2020/10/20 06:27 [entrez]
AID - 10.1111/epi.16707 [doi]
PST - ppublish
SO  - Epilepsia. 2020 Dec;61(12):2643-2652. doi: 10.1111/epi.16707. Epub 2020 Oct 19.