PMID- 33078488
OWN - NLM
STAT- MEDLINE
DCOM- 20210816
LR  - 20210816
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 27
IP  - 6
DP  - 2021 Sep
TI  - Is hyperglycemia the only risk factor for implant in type 2 diabetics during the 
      healing period?
PG  - 1551-1563
LID - 10.1111/odi.13685 [doi]
AB  - OBJECTIVE: To determine whether risk factors other than hyperglycemia lead to 
      failed osseointegration in patients with type 2 diabetes mellitus (T2DM) during 
      the healing period. MATERIALS AND METHODS: We compared the success rates between 
      patients with and without T2DM during the healing period at our center. Bone 
      marrow mesenchymal stem cells (BMSCs) were cultured from subjects. Proteomics was 
      used to detect differentially expressed proteins (DEPs) among the DM failure 
      (DM-F), DM success (DM-S), and control (Con) groups. The correlation between the 
      expression levels of nine target DEPs and medium glucose concentrations was 
      investigated. RESULTS: Higher failure rates were observed in the T2DM patients. 
      Fifty-two DEPs were found between the DM-F and DM-S groups. Seventy-three DEPs 
      were found between the DM-F and Con groups. Forty-three DEPs were found between 
      the DM-S and Con groups. Five target DEPs were expressed at the same levels in 
      the medium with different glucose concentrations. Gene ontology annotation and 
      functional enrichment analysis suggest that the DEPs detected in the DM-F group 
      may affect the biological function and regulatory potential of BMSCs. 
      CONCLUSIONS: The DEPs detected in the DM-F group can be intervention targets for 
      to prevent implant failure in T2DM patients. Risk factors besides hyperglycemia 
      may affect osseointegration during healing period.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Tang, Dezheng
AU  - Tang D
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Wang, Entang
AU  - Wang E
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Xu, Yifan
AU  - Xu Y
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Liang, Chao
AU  - Liang C
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Liu, Changying
AU  - Liu C
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Lin, Xiao
AU  - Lin X
AUID- ORCID: 0000-0003-2789-0720
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
FAU - Li, Jun
AU  - Li J
AUID- ORCID: 0000-0002-9301-6073
AD  - Department of Dental Implant Center, Beijing Stomatological Hospital, School of 
      Stomatology, Capital Medical University, Beijing, China.
AD  - Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School 
      of Stomatology, Capital Medical University, Beijing, China.
LA  - eng
GR  - 81371115/National Natural Science Foundation of China/
GR  - PYZ2018040/Scientific Research Nurturing Foundation of Beijing Stomatological 
      Hospital, Capital Medical University/
GR  - 18-09-17/Beijing Stomatological Hospital, Capital Medical University Discipline 
      Construction Foundation/
GR  - 17-09-06/Beijing Stomatological Hospital, Capital Medical University Discipline 
      Construction Foundation/
PT  - Journal Article
DEP - 20201120
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
RN  - 0 (Dental Implants)
MH  - *Dental Implants
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - *Hyperglycemia/complications
MH  - Osseointegration
MH  - Risk Factors
OTO - NOTNLM
OT  - bone marrow mesenchymal stem cells
OT  - dental implants
OT  - osseointegration
OT  - proteomics
OT  - type 2 diabetes
EDAT- 2020/10/21 06:00
MHDA- 2021/08/17 06:00
CRDT- 2020/10/20 06:28
PHST- 2020/10/02 00:00 [revised]
PHST- 2020/07/07 00:00 [received]
PHST- 2020/10/09 00:00 [accepted]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/08/17 06:00 [medline]
PHST- 2020/10/20 06:28 [entrez]
AID - 10.1111/odi.13685 [doi]
PST - ppublish
SO  - Oral Dis. 2021 Sep;27(6):1551-1563. doi: 10.1111/odi.13685. Epub 2020 Nov 20.