PMID- 33078848
OWN - NLM
STAT- MEDLINE
DCOM- 20210820
LR  - 20210820
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 51
IP  - 3
DP  - 2021 Mar
TI  - Plasmacytoid dendritic cells regulate host immune response to Citrobacter 
      rodentium induced colitis in colon-draining lymph nodes.
PG  - 620-625
LID - 10.1002/eji.202048714 [doi]
AB  - Dendritic cells (DCs) are first in line to sense invading microbes and to deliver 
      signals to other immune cells. Plasmacytoid DCs (pDC) produce high amounts of 
      type I interferons (IFNs) but also regulate immune responses. Using the Clec4C 
      (BDCA2)-diphtheria toxin receptor mouse model allowing conditional pDC depletion, 
      we identified an essential role for pDCs in regulating intestinal inflammation 
      locally in the gut. In pDC-depleted mice, Citrobacter rodentium infection led to 
      enhanced activation of conventional DCs and induction of IFN-gamma-producing 
      Th1-cells in colon-draining lymph nodes, while induction of Foxp3(+) /CD25(+) 
      Treg and IL-17-producing Th17 cells was impaired. Concomitantly, F4/80(+) 
      macrophages accumulated into the colon lamina propria in excess, and levels of 
      Il-1beta and Tnf transcripts increased and Foxp3(+) Treg were fewer. Our results 
      indicate that pDCs control inflammation in the gut during C. rodentium infection 
      and that they have an important immune regulatory role in colon-draining lymph 
      nodes.
CI  - (c) 2020 Wiley-VCH GmbH.
FAU - Poysti, Sakari
AU  - Poysti S
AUID- ORCID: 0000-0001-8639-3391
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
AD  - Department of Clinical Microbiology and Immunology, Turku University Hospital, 
      Turku, Finland.
FAU - Silojarvi, Satu
AU  - Silojarvi S
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
FAU - Toivonen, Raine
AU  - Toivonen R
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
FAU - Hanninen, Arno
AU  - Hanninen A
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
AD  - Department of Clinical Microbiology and Immunology, Turku University Hospital, 
      Turku, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201130
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Heparin-binding EGF-like Growth Factor)
RN  - 0 (Interleukin-2 Receptor alpha Subunit)
SB  - IM
MH  - Animals
MH  - Citrobacter rodentium/*immunology
MH  - Colitis/*immunology
MH  - Colon/*immunology
MH  - Dendritic Cells/*immunology
MH  - Enterobacteriaceae Infections/immunology
MH  - Female
MH  - Forkhead Transcription Factors/immunology
MH  - Heparin-binding EGF-like Growth Factor/immunology
MH  - Immunity/*immunology
MH  - Inflammation/immunology
MH  - Interleukin-2 Receptor alpha Subunit/immunology
MH  - Intestinal Mucosa/immunology
MH  - Lymph Nodes/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Th1 Cells/immunology
MH  - Th17 Cells/immunology
OTO - NOTNLM
OT  - Clec4C (BDCA2) mice
OT  - T cells
OT  - colitis
OT  - gut immune system
OT  - plasmacytoid dendritic cells
EDAT- 2020/10/21 06:00
MHDA- 2021/08/21 06:00
CRDT- 2020/10/20 08:38
PHST- 2020/04/22 00:00 [received]
PHST- 2020/10/05 00:00 [revised]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/08/21 06:00 [medline]
PHST- 2020/10/20 08:38 [entrez]
AID - 10.1002/eji.202048714 [doi]
PST - ppublish
SO  - Eur J Immunol. 2021 Mar;51(3):620-625. doi: 10.1002/eji.202048714. Epub 2020 Nov 
      30.