PMID- 33079256
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 2366-0058 (Electronic)
VI  - 46
IP  - 5
DP  - 2021 May
TI  - Feasibility of wide detector CT perfusion imaging performed during routine 
      staging and restaging of pancreatic ductal adenocarcinoma.
PG  - 1992-2002
LID - 10.1007/s00261-020-02786-y [doi]
AB  - PURPOSE: To evaluate the feasibility of CT perfusion performed during routine 
      multiphase contrast-enhanced CT on a 160 mm wide-coverage 256-slice scanner in 
      patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Fifty-seven 
      patients had a CT perfusion acquisition during their routine multiphase 
      CT. Perfusion was performed 5 to 42.5 s (15 passes at 2.5 s intervals) after 
      intravenous contrast administration (4.2-5 ml/s), followed by pancreatic 
      parenchymal and portal venous phases for clinical interpretation. Perfusion maps 
      were generated and blood flow (BF), blood volume (BV), and permeability surface 
      area product (PS) for tumor and uninvolved pancreas were calculated using 
      deconvolution algorithms and compared to existing similar publications. 
      Radiation dose information was recorded and size-specific dose estimate 
      (SSDE) was calculated using body dimensions. RESULTS: Diagnostic quality of 
      standard images was unaffected by performing the perfusion acquisition. Average 
      tumor center BF was 20.8 +/- 12.1 ml/100 g/min, BV 2.5 +/- 2.1 ml/100 g and PS 
      15.5 +/- 39.4 ml/100 g/min. Average pancreas BF was 90.8 +/- 50.2 ml/100 g/min, BV 
      11.9 +/- 4.3 ml/100 g and PS 33.6 +/- 27.7 ml/100 g/min. For the perfusion 
      acquisition, mean SSDE was 57 +/- 11 mGy, CTDI(vol) 43 +/- 6 mGy and DLP 
      685 +/- 100 mGy-cm. CONCLUSION: Adding a perfusion CT acquisition to standard 
      pancreatic CT protocol is feasible using a wide-detector 256-slice CT scanner and 
      adds quantitative information while maintaining diagnostic quality of the 
      standard of care examination. This novel protocol adds no time or cost to the 
      examination and yields perfusion parameters that are comparable to existing 
      literature using a separate dedicated perfusion protocol.
FAU - O'Malley, Ryan B
AU  - O'Malley RB
AUID- ORCID: 0000-0002-5338-3354
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA. ryanomal@uw.edu.
FAU - Soloff, Erik V
AU  - Soloff EV
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA.
FAU - Coveler, Andrew L
AU  - Coveler AL
AD  - Department of Medicine, Division of Oncology, University of Washington School of 
      Medicine, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
FAU - Cox, Danielle H
AU  - Cox DH
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA.
FAU - Desai, Nitin
AU  - Desai N
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA.
FAU - Busey, Janet M
AU  - Busey JM
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA.
FAU - Valentin, Greta M
AU  - Valentin GM
AD  - Seattle Cancer Care Alliance, 825 Eastlake Ave E, Seattle, WA, 98109, USA.
FAU - Wang, Carolyn L
AU  - Wang CL
AD  - Department of Radiology, University of Washington School of Medicine, 1959 NE 
      Pacific Street, Box 357115, Seattle, WA, 98195, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201020
PL  - United States
TA  - Abdom Radiol (NY)
JT  - Abdominal radiology (New York)
JID - 101674571
SB  - IM
MH  - *Adenocarcinoma
MH  - Feasibility Studies
MH  - Humans
MH  - *Pancreatic Neoplasms/diagnostic imaging
MH  - Perfusion Imaging
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - CT perfusion
OT  - Computed tomography
OT  - Oncology imaging
OT  - Pancreas
OT  - Pancreatic ductal adenocarcinoma
EDAT- 2020/10/21 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/20 12:13
PHST- 2020/07/06 00:00 [received]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/20 12:13 [entrez]
AID - 10.1007/s00261-020-02786-y [pii]
AID - 10.1007/s00261-020-02786-y [doi]
PST - ppublish
SO  - Abdom Radiol (NY). 2021 May;46(5):1992-2002. doi: 10.1007/s00261-020-02786-y. 
      Epub 2020 Oct 20.