PMID- 33079302 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20220531 IS - 1434-9949 (Electronic) IS - 0770-3198 (Linking) VI - 40 IP - 5 DP - 2021 May TI - Urinary levels of ceruloplasmin and monocyte chemoattractant protein-1 correlate with extra-capillary proliferation and chronic damage in patients with lupus nephritis. PG - 1853-1859 LID - 10.1007/s10067-020-05454-0 [doi] AB - BACKGROUND AND AIM: There are few studies of urinary biomarkers and histopathologic features in lupus nephritis (LN). The aim was to analyze the correlation between a wide panel of urinary biomarkers and serum concentrations of anti C1q antibodies with histological items of activity and chronicity on kidney biopsy in LN patients. METHODS: Patients with systemic lupus erythematosus (SLE) according to American College of Rheumatology (ACR) criteria were included. LN diagnosis was based on ACR criteria. Histologic features of activity and chronicity indices were analyzed according to the Austin classification. Serum Anti C1q levels were determined by commercial ELISA. Urinary levels of transferrin, ceruloplasmin (CP), VCAM-1, TWEAK, monocyte chemoattractant protein-1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), and alpha-1-acid glycoprotein were measured by commercial ELISA. RESULTS: We included 120 SLE patients (81% female, mean age 33.1 +/- 9.3 years, 59.4% Mestizo, 37.8% Afro-Latin American): 64% had LN. Kidney biopsy was performed in 55 patients, but only 37 were made in our center. Anti C1q antibodies were associated with endocapillary proliferation. In patients with cellular crescents, urinary concentrations of CP were significantly higher. In patients with a chronicity index (CI) >/= 4, fibrous crescents, tubular atrophy, and interstitial fibrosis, urinary MCP-1 levels were higher. CONCLUSIONS: In SLE patients, serum anti C1q antibodies and urinary CP were associated with activity on kidney biopsy and MCP-1 with chronic damage. This panel of biomarkers could be validated in larger, multi-ethnic population as a complementary tool for better stratification of LN patients. Key Points * Urinary biomarkers are complementary useful tools for the assessment of SLE patients. * Urinary levels of CP correlated with activity findings on kidney biopsy in LN patients. * Urinary levels of MCP-1 correlated with chronic damage, especially with fibrous crescents, tubular atrophy, and interstitial fibrosis. FAU - Urrego-Callejas, Tomas AU - Urrego-Callejas T AD - Grupo de Inmunologia Celular e Inmunogenetica, Universidad de Antioquia, Medellin, Colombia. FAU - Alvarez, Simon Sandoval AU - Alvarez SS AD - Grupo de Inmunologia Celular e Inmunogenetica, Universidad de Antioquia, Medellin, Colombia. FAU - Arias, Luis F AU - Arias LF AD - Departamento de Patologia, Universidad de Antioquia y Hospital Universitario de San Vicente Fundacion, Medellin, Colombia. FAU - Reyes, Blanca Ortiz AU - Reyes BO AD - Grupo de Inmunologia Celular e Inmunogenetica, Universidad de Antioquia, Medellin, Colombia. FAU - Vanegas-Garcia, Adriana L AU - Vanegas-Garcia AL AD - Grupo de Reumatologia, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia. AD - Servicio de Reumatologia, Hospital Universitario de San Vicente Fundacion, Medellin, Colombia. FAU - Gonzalez, Luis A AU - Gonzalez LA AD - Grupo de Reumatologia, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia. FAU - Munoz-Vahos, Carlos H AU - Munoz-Vahos CH AD - Grupo de Reumatologia, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia. AD - Servicio de Reumatologia, Hospital Universitario de San Vicente Fundacion, Medellin, Colombia. FAU - Vasquez, Gloria AU - Vasquez G AD - Grupo de Inmunologia Celular e Inmunogenetica, Universidad de Antioquia, Medellin, Colombia. AD - Grupo de Reumatologia, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia. FAU - Quintana, Luis F AU - Quintana LF AD - Centro de Referencia en Enfermedad Glomerular Compleja del Sistema Nacional de Salud (CSUR), Servicio de Nefrologia y Trasplante Renal, Hospital Clinic, Barcelona, Spain. FAU - Gomez-Puerta, Jose A AU - Gomez-Puerta JA AUID- ORCID: 0000-0001-8177-702X AD - Grupo de Inmunologia Celular e Inmunogenetica, Universidad de Antioquia, Medellin, Colombia. jagomez@clinic.cat. AD - Rheumatology Department, Hospital Clinic, Barcelona, Spain. jagomez@clinic.cat. LA - eng PT - Journal Article DEP - 20201020 PL - Germany TA - Clin Rheumatol JT - Clinical rheumatology JID - 8211469 RN - 0 (Biomarkers) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - EC 1.16.3.1 (Ceruloplasmin) SB - IM MH - Adult MH - Biomarkers MH - Cell Proliferation MH - Ceruloplasmin/*urine MH - Chemokine CCL2/*urine MH - Female MH - Humans MH - *Lupus Erythematosus, Systemic/pathology MH - *Lupus Nephritis/pathology MH - Male MH - Young Adult OTO - NOTNLM OT - Activity OT - Anti C1q antibodies OT - Biomarkers OT - Chronicity OT - Kidney biopsy OT - Lupus nephritis OT - Systemic lupus erythematosus EDAT- 2020/10/21 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/10/20 12:13 PHST- 2020/06/02 00:00 [received] PHST- 2020/10/06 00:00 [accepted] PHST- 2020/10/05 00:00 [revised] PHST- 2020/10/21 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/10/20 12:13 [entrez] AID - 10.1007/s10067-020-05454-0 [pii] AID - 10.1007/s10067-020-05454-0 [doi] PST - ppublish SO - Clin Rheumatol. 2021 May;40(5):1853-1859. doi: 10.1007/s10067-020-05454-0. Epub 2020 Oct 20.