PMID- 33080444
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 174
DP  - 2020 Nov-Dec
TI  - Clinical significance of minor salivary gland biopsy in patients with idiopathic 
      interstitial pneumonia.
PG  - 106189
LID - S0954-6111(20)30329-2 [pii]
LID - 10.1016/j.rmed.2020.106189 [doi]
AB  - BACKGROUND: Significant overlap may occur between idiopathic interstitial 
      pneumonia (IIP) and connective tissue diseases (CTDs) that do not meet the 
      established classification criteria for any known CTDs (i.e., occult CTD). 
      Performing minor salivary gland biopsy (MSGB) to detect occult primary Sjogren's 
      syndrome (pSS) in IIP patients is not well studied. METHODS: Consecutive IIP 
      patients underwent MSGB to determine the prevalence of positive MSGB findings. 
      Furthermore, we characterised the clinical, physiological and serological 
      profiles of the MSGB-positive patients. Cox regression models were used to 
      identify independent predictors of survival. RESULTS: The data of 155 patients 
      with IIP were available for analysis. Sixty patients (38.7%) had positive MSGB 
      findings. Of them, the mean age was 63.3 years, 51.6% were women, usual 
      interstitial pneumonia (UIP) was the predominant pattern (63.3%), and 
      seronegative antibodies (61.6%) were likely. Patients with positive MSGB findings 
      had significantly greater survival than those with negative MSGB findings 
      (p = 0.041). After stratifying the MSGB cohort based on the presence of a UIP 
      pattern, no significant difference in survival was noted between those with 
      positive MSGB-UIP pattern and those with a negative MSGB-UIP pattern (p = 0.231). 
      Multivariate analysis on all UIP patients showed that higher forced vital 
      capacity (p = 0.010) and smoking status (p = 0.035) were independently associated 
      with survival. CONCLUSIONS: A substantial number of IIP patients had underlying 
      occult CTD, highlighting the importance of performing MSGB to identify the 
      salivary component of pSS when evaluating patients with interstitial lung disease 
      of undetermined aetiology.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Alhamad, Esam H
AU  - Alhamad EH
AD  - Department of Medicine, Division of Pulmonary Medicine, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia. Electronic address: esamalhamad@yahoo.com.
FAU - Cal, Joseph G
AU  - Cal JG
AD  - Department of Medicine, Division of Pulmonary Medicine, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia.
FAU - Paramasivam, Muthurajan P
AU  - Paramasivam MP
AD  - Department of Medicine, Division of Pulmonary Medicine, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia.
FAU - AlEssa, Mohammed
AU  - AlEssa M
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia.
FAU - Alrajhi, Nuha N
AU  - Alrajhi NN
AD  - Department of Medicine, Division of Pulmonary Medicine, College of Medicine, King 
      Saud University, Riyadh, Saudi Arabia.
FAU - Omair, Mohammed A
AU  - Omair MA
AD  - Department of Medicine, Division of Rheumatology Medicine, College of Medicine, 
      King Saud University, Riyadh, Saudi Arabia.
FAU - AlRikabi, Ammar C
AU  - AlRikabi AC
AD  - Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - AlBoukai, Ahmad A
AU  - AlBoukai AA
AD  - Department of Radiology, College of Medicine, King Saud University, Riyadh, Saudi 
      Arabia.
LA  - eng
PT  - Journal Article
DEP - 20201009
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Aged
MH  - Biopsy/*methods
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*diagnosis/etiology/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Salivary Glands/*pathology
MH  - Sjogren's Syndrome/complications/diagnosis/pathology
MH  - Survival Rate
OTO - NOTNLM
OT  - Idiopathic interstitial pneumonia
OT  - Idiopathic pulmonary fibrosis
OT  - Minor salivary gland biopsy
OT  - Occult connective tissue disease
OT  - Primary Sjogren's syndrome
OT  - Survival
EDAT- 2020/10/21 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/20 20:10
PHST- 2020/06/13 00:00 [received]
PHST- 2020/09/21 00:00 [revised]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/21 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/20 20:10 [entrez]
AID - S0954-6111(20)30329-2 [pii]
AID - 10.1016/j.rmed.2020.106189 [doi]
PST - ppublish
SO  - Respir Med. 2020 Nov-Dec;174:106189. doi: 10.1016/j.rmed.2020.106189. Epub 2020 
      Oct 9.