PMID- 33080708
OWN - NLM
STAT- MEDLINE
DCOM- 20201030
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 42
DP  - 2020 Oct 16
TI  - Adenomyoepithelioma with a human epidermal growth factor receptor 2-fluorescence 
      in situ hybridization-confirmed ductal carcinoma in situ component: A case report 
      and review of the literature.
PG  - e22665
LID - 10.1097/MD.0000000000022665 [doi]
LID - e22665
AB  - INTRODUCTION: Breast adenomyoepithelioma (AME) is a rare tumor composed of 
      myoepithelial cells and ductal or luminal cells. Most cases of AME are benign, 
      but rare cases in which either or both cell types exhibited malignant features 
      have been reported. Due to its rarity, no diagnostic criteria for malignancy have 
      been established for AME. PATIENT CONCERNS: A 64-year-old woman presented with a 
      mass in her right breast. Fine-needle aspiration cytology and biopsy examinations 
      revealed lesions composed of spindle-shaped cells and round epithelial cells. AME 
      was suspected, and partial mastectomy was performed. DIAGNOSIS: The tumor 
      specimen showed AME, which mainly consisted of spindle-shaped myoepithelial cells 
      with slight atypia, admixed with tubular luminal cells and small areas of 
      atypical intraductal proliferative lesions. No apparent features of malignancy, 
      such as necrosis or invasion, were seen in the myoepithelial cells or the luminal 
      or intraductal component. However, the atypical intraductal component exhibited 
      focal nuclear atypia, a cribriform pattern, and moderate to strong membranous 
      human epidermal growth factor receptor 2 (HER2) immunoreactivity. HER2 
      amplification was detected in focal regions of the atypical intraductal component 
      by fluorescence in situ hybridization (FISH), which resulted in a diagnosis of 
      AME with ductal carcinoma in situ. OUTCOMES: The patient did not receive further 
      therapy and was free from tumor recurrence at 23 months after the operation. 
      CONCLUSION: HER2 FISH might be useful for evaluating suspected AME tumors for 
      malignancy when an atypical ductal lesion that lacks definitive features of 
      malignancy is encountered.
FAU - Amano, Yusuke
AU  - Amano Y
AUID- ORCID: 0000-0002-4056-3487
AD  - Department of Pathology.
FAU - Sakaguchi-Tamba, Mio
AU  - Sakaguchi-Tamba M
AD  - Department of Pathology.
FAU - Sasaki, Yumiko
AU  - Sasaki Y
AD  - Department of Breast Surgery, Jichi Medical University, Shimotsuke, Tochigi.
FAU - Oshiro, Hisashi
AU  - Oshiro H
AD  - Department of Pathology.
FAU - Fukushima, Noriyoshi
AU  - Fukushima N
AD  - Department of Pathology.
FAU - Fujita, Takashi
AU  - Fujita T
AD  - Department of Breast Surgery, Jichi Medical University, Shimotsuke, Tochigi.
FAU - Masuda, Shinobu
AU  - Masuda S
AD  - Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon 
      University School of Medicine, Itabashi, Tokyo, Japan.
FAU - Niki, Toshiro
AU  - Niki T
AD  - Department of Pathology.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adenomyoepithelioma/*pathology
MH  - Breast Neoplasms/*pathology
MH  - Carcinoma, Intraductal, Noninfiltrating/chemistry/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Receptor, ErbB-2/*analysis
PMC - PMC7572011
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/10/22 06:00
MHDA- 2020/10/31 06:00
PMCR- 2020/10/16
CRDT- 2020/10/21 01:01
PHST- 2020/10/21 01:01 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2020/10/31 06:00 [medline]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 00005792-202010160-00041 [pii]
AID - MD-D-20-00972 [pii]
AID - 10.1097/MD.0000000000022665 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Oct 16;99(42):e22665. doi: 
      10.1097/MD.0000000000022665.