PMID- 33080733
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 42
DP  - 2020 Oct 16
TI  - Efficacy and safety of acupoint injection therapy for allergic rhinitis: A 
      protocol for systematic review and meta-analysis.
PG  - e22737
LID - 10.1097/MD.0000000000022737 [doi]
LID - e22737
AB  - BACKGROUND: Allergic rhinitis (AR), characterized by nasal itching, sneezing, and 
      congestion, is a common disorder of nose. In the United States, AR affects 10% to 
      20% of adults. The negative impact of the high prevalence of AR has caused a 
      great economic burdens worldwide. Modern Western Medicine mainly treats AR with 
      antihistamine drugs, glucocorticoids, allergic immunotherapy (AIT), but it 
      seriously affects patients compliance because of its long course of treatment, 
      high medical costs and side effect. And now, as an important mean of treating AR, 
      acupoint injection has been widely used in clinics, and has achieved significant 
      efficacy. METHODS AND ANALYSIS: The following databases will be searched for 
      relevant information before July 2020: PubMed, Embase, Cochrane Library, Web of 
      Science, and CNKI. MAJOR RESULTS: scores of Rhinitis Quality of Life (RQLQ), 
      Rhinitis Total Symptom Scores (RTSS). Secondary results: levels of 
      antigen-specific serum immunoglobulin E (IgE), total effective rate, adverse 
      event. Data will be collected independently by 2 researchers, and the risk of 
      bias in meta-analysis will be evaluated according to "Cochrane Handbook for 
      Systematic Reviews of Interventions". All data analysis will be conducted using 
      Review Manager V.5.3. and Stata V.12.0. RESULTS: The curative effect and safety 
      of acupoint injection treatment for AR patients will be evaluated systematically. 
      CONCLUSION: The systematic review of this study will summarize the currently 
      published evidence of acupoint injection treatment for AR to further guide its 
      promotion and application. ETHICS AND DISSEMINATION: The private information from 
      individuals will not be published. This systematic review also will not involve 
      endangering participant rights. Ethical approval is not required. The results may 
      be published in a peer-reviewed journal or disseminated in relevant 
      conferences.Open Science Framework (OSF) registration number: 
      https://osf.io/fa9dq.
FAU - Chen, Zhenfeng
AU  - Chen Z
AUID- ORCID: 0000-0002-4820-6089
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Xing, Shasha
AU  - Xing S
AD  - Ruikang Hospital affiliated to Guangxi University of Chinese Medicine, Nanning, 
      Guangxi Province.
FAU - Huang, Yingzhuan
AU  - Huang Y
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Zeng, Qifeng
AU  - Zeng Q
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Xu, Donghan
AU  - Xu D
AD  - Macau University of Science and Technology, College of Traditional Chinese 
      Medicine Macau.
FAU - He, Qiumei
AU  - He Q
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Qin, Huangguan
AU  - Qin H
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Luo, Xiaofan
AU  - Luo X
AD  - Guangxi university of Traditional Chinese Medicine.
FAU - Li, Renfeng
AU  - Li R
AUID- ORCID: 0000-0001-5893-1463
AD  - The first Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, 
      Guangxi Province, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - *Acupuncture Therapy
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - Research Design
MH  - Rhinitis, Allergic/*therapy
MH  - *Systematic Reviews as Topic
PMC - PMC7572024
COIS- All authors involved in this work have no conflicts of interest.
EDAT- 2020/10/22 06:00
MHDA- 2020/11/03 06:00
PMCR- 2020/10/16
CRDT- 2020/10/21 01:01
PHST- 2020/10/21 01:01 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 00005792-202010160-00066 [pii]
AID - MD-D-20-08953 [pii]
AID - 10.1097/MD.0000000000022737 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Oct 16;99(42):e22737. doi: 
      10.1097/MD.0000000000022737.