PMID- 33080952
OWN - NLM
STAT- MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 20
DP  - 2020 Oct 18
TI  - The Wnt Signalling Pathway: A Tailored Target in Cancer.
LID - 10.3390/ijms21207697 [doi]
LID - 7697
AB  - Cancer is one of the greatest public health challenges. According to the World 
      Health Organization (WHO), 9.6 million cancer deaths have been reported in 2018. 
      The most common cancers include lung, breast, colorectal, prostate, skin 
      (non-melanoma) and stomach cancer. The unbalance of physiological signalling 
      pathways due to the acquisition of mutations in tumour cells is considered the 
      most common cancer driver. The Wingless-related integration site (Wnt)/beta-catenin 
      pathway is crucial for tissue development and homeostasis in all animal species 
      and its dysregulation is one of the most relevant events linked to cancer 
      development and dissemination. The canonical and the non-canonical Wnt/beta-catenin 
      pathways are known to control both physiological and pathological processes, 
      including cancer. Herein, the impact of the Wnt/beta-catenin cascade in driving 
      cancers from different origin has been examined. Finally, based on the impact of 
      Extracellular Vesicles (EVs) on tumour growth, invasion and chemoresistance, and 
      their role as tumour diagnostic and prognostic tools, an overview of the current 
      knowledge linking EVs to the Wnt/beta-catenin pathway is also discussed.
FAU - Koni, Malvina
AU  - Koni M
AD  - Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 
      Turin, Italy.
FAU - Pinnaro, Veronica
AU  - Pinnaro V
AD  - Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 
      Turin, Italy.
FAU - Brizzi, Maria Felice
AU  - Brizzi MF
AD  - Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126 
      Turin, Italy.
LA  - eng
GR  - IG 2015.17630/Associazione Italiana per la Ricerca sul Cancro/
GR  - #2019/Ministero dell'Istruzione, Universita e Ricerca (MIUR) ex 60%./
PT  - Journal Article
PT  - Review
DEP - 20201018
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Cell Polarity
MH  - Extracellular Vesicles/metabolism
MH  - Humans
MH  - MicroRNAs/genetics/metabolism
MH  - *Molecular Targeted Therapy
MH  - Neoplasms/genetics/*metabolism/*therapy
MH  - *Wnt Signaling Pathway
PMC - PMC7589708
OTO - NOTNLM
OT  - Wnt/beta-catenin dependent pathway
OT  - Wnt/beta-catenin independent pathway
OT  - breast cancer
OT  - colorectal cancer
OT  - extracellular vesicles
OT  - ovarian cancer
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/22 06:00
MHDA- 2021/02/24 06:00
PMCR- 2020/10/01
CRDT- 2020/10/21 01:02
PHST- 2020/09/29 00:00 [received]
PHST- 2020/10/15 00:00 [revised]
PHST- 2020/10/16 00:00 [accepted]
PHST- 2020/10/21 01:02 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2021/02/24 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijms21207697 [pii]
AID - ijms-21-07697 [pii]
AID - 10.3390/ijms21207697 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 18;21(20):7697. doi: 10.3390/ijms21207697.