PMID- 33080955
OWN - NLM
STAT- MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 20
DP  - 2020 Oct 18
TI  - Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems.
LID - 10.3390/ijms21207698 [doi]
LID - 7698
AB  - Elevated concentration of homocysteine (Hcy) in the blood plasma, 
      hyperhomocysteinemia (HHcy), has been implicated in various disorders, including 
      cardiovascular and neurodegenerative diseases. Accumulating evidence indicates 
      that pathophysiology of these diseases is linked with mitochondrial dysfunction. 
      In this review, we discuss the current knowledge concerning the effects of HHcy 
      on mitochondrial homeostasis, including energy metabolism, mitochondrial 
      apoptotic pathway, and mitochondrial dynamics. The recent studies suggest that 
      the interaction between Hcy and mitochondria is complex, and reactive oxygen 
      species (ROS) are possible mediators of Hcy effects. We focus on mechanisms 
      contributing to HHcy-associated oxidative stress, such as sources of ROS 
      generation and alterations in antioxidant defense resulting from altered gene 
      expression and post-translational modifications of proteins. Moreover, we discuss 
      some recent findings suggesting that HHcy may have beneficial effects on 
      mitochondrial ROS homeostasis and antioxidant defense. A better understanding of 
      complex mechanisms through which Hcy affects mitochondrial functions could 
      contribute to the development of more specific therapeutic strategies targeted at 
      HHcy-associated disorders.
FAU - Kaplan, Peter
AU  - Kaplan P
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius 
      University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia.
FAU - Tatarkova, Zuzana
AU  - Tatarkova Z
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius 
      University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia.
FAU - Sivonova, Monika Kmetova
AU  - Sivonova MK
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius 
      University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia.
FAU - Racay, Peter
AU  - Racay P
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius 
      University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia.
FAU - Lehotsky, Jan
AU  - Lehotsky J
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius 
      University in Bratislava, Mala Hora 4D, 036 01 Martin, Slovakia.
LA  - eng
GR  - 1/0004/19/Vedecka Grantova Agentura MSVVaS SR a SAV/
GR  - 26220220114/EU sources and European Regional Development Fund/
PT  - Journal Article
PT  - Review
DEP - 20201018
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - Brain/*blood supply
MH  - Cardiovascular System/*metabolism
MH  - Energy Metabolism
MH  - Homocysteine/chemistry/*metabolism
MH  - Humans
MH  - Mitochondria/*metabolism
MH  - Oxidative Stress
PMC - PMC7589705
OTO - NOTNLM
OT  - ROS
OT  - brain
OT  - heart
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - mitochondria
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/22 06:00
MHDA- 2021/02/24 06:00
PMCR- 2020/10/01
CRDT- 2020/10/21 01:02
PHST- 2020/10/02 00:00 [received]
PHST- 2020/10/15 00:00 [revised]
PHST- 2020/10/16 00:00 [accepted]
PHST- 2020/10/21 01:02 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2021/02/24 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijms21207698 [pii]
AID - ijms-21-07698 [pii]
AID - 10.3390/ijms21207698 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 18;21(20):7698. doi: 10.3390/ijms21207698.