PMID- 33083350
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2284-2594 (Electronic)
IS  - 2284-2594 (Linking)
VI  - 7
IP  - 10
DP  - 2020
TI  - Angioimmunoblastic T-cell Lymphoma: A Mimic for Lupus.
PG  - 001734
LID - 10.12890/2020_001734 [doi]
LID - 001734
AB  - New-onset systemic lupus erythematosus (SLE) is uncommon in elderly patients. We 
      report the case of a 71-year-old woman who was diagnosed with SLE based on 
      clinical manifestations of fever, alopecia, bicytopenia, hepatomegaly, 
      lymphadenopathy, glomerulonephritis, positive antinuclear antibody (ANA) and 
      anti-double stranded DNA (anti-dsDNA) antibody. Renal biopsy was consistent with 
      lupus nephritis and excision biopsy of a right inguinal lymph node was initially 
      reported as having features of reactive hyperplasia. However, a more careful 
      review of the lymph node biopsy subsequently confirmed a concurrent 
      angioimmunoblastic T-cell lymphoma. This case illustrates the importance of 
      investigating secondary causes and possible alternative diagnoses in patients who 
      present with atypical features of connective tissue disease, and the challenges 
      in diagnosing a rare form of lymphoma. LEARNING POINTS: A thorough work-up for 
      secondary causes and careful evaluation to exclude possible alternative diagnoses 
      is important in cases of elderly-onset lupus.The disease presentations of lupus 
      and haematological malignancies such as lymphoma may mimic each other and 
      differentiation between the two can be clinically challenging; lupus can be 
      associated with cytopenias, hepatomegaly and lymphadenopathy, but the degree of 
      severity and the context of the clinical presentation need to be considered 
      carefully before attributing these features to it.As some lymphomas are rare and 
      difficult to diagnose, if there is a high clinical suspicion despite negative 
      histological studies, discussion with the pathologist is important and a review 
      of histology should be sought.
CI  - (c) EFIM 2020.
FAU - Tay, Hui Boon
AU  - Tay HB
AD  - Division of Medicine, Sengkang General Hospital, SingHealth, Singapore.
FAU - Angkodjojo, Stanley
AU  - Angkodjojo S
AD  - Division of Medicine, Sengkang General Hospital, SingHealth, Singapore.
FAU - Tay, Zhi En Amos
AU  - Tay ZEA
AD  - Department of Anatomical Pathology, Singapore General Hospital, SingHealth, 
      Singapore.
FAU - Tan, Puay Hoon
AU  - Tan PH
AD  - Division of Pathology, Singapore General Hospital, SingHealth, Singapore.
FAU - Tan, Yan Denise
AU  - Tan YD
AD  - Division of Medicine, Sengkang General Hospital, SingHealth, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20200715
PL  - Italy
TA  - Eur J Case Rep Intern Med
JT  - European journal of case reports in internal medicine
JID - 101648453
PMC - PMC7546564
OTO - NOTNLM
OT  - Elderly-onset systemic lupus erythematosus
OT  - angioimmunoblastic T-cell lymphoma
OT  - lupus nephritis
COIS- Conflicts of Interests: The Authors declare that there are no competing 
      interests.
EDAT- 2020/10/22 06:00
MHDA- 2020/10/22 06:01
PMCR- 2020/07/15
CRDT- 2020/10/21 06:04
PHST- 2020/05/20 00:00 [received]
PHST- 2020/06/24 00:00 [accepted]
PHST- 2020/10/21 06:04 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2020/10/22 06:01 [medline]
PHST- 2020/07/15 00:00 [pmc-release]
AID - 1734-1-15063-1-10-20200712 [pii]
AID - 10.12890/2020_001734 [doi]
PST - epublish
SO  - Eur J Case Rep Intern Med. 2020 Jul 15;7(10):001734. doi: 10.12890/2020_001734. 
      eCollection 2020.