PMID- 33085703
OWN - NLM
STAT- MEDLINE
DCOM- 20201211
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 10
DP  - 2020
TI  - Burden, predictors and short-term outcomes of peripartum cardiomyopathy in a 
      black African cohort.
PG  - e0240837
LID - 10.1371/journal.pone.0240837 [doi]
LID - e0240837
AB  - BACKGROUND: Peripartum cardiomyopathy (PPCM) is an idiopathic cardiomyopathy 
      presenting with acute heart failure during the peripartum period. It is common in 
      patients of African ancestry. Currently, there is paucity of data on the burden, 
      predictors and outcomes of PPCM in Uganda. This study aimed to investigate the 
      prevalence, predictors and six-month outcomes of PPCM in an adult cohort 
      attending a tertiary specialised cardiology centre in Kampala, Uganda. METHODS: 
      This study consecutively enrolled 236 women presenting with features of acute 
      heart failure in the peripartum period. Clinical evaluation and echocardiography 
      were performed on all the enrolled women. PCCM was defined according to 
      recommendations of the Heart Failure Association of the European Society of 
      Cardiology Working Group on PPCM. Poor outcome at six months of follow-up was 
      defined as presence of any of the following: death of a mother or her baby, New 
      York Heart Association (NYHA) functional class III-IV or failure to achieve 
      complete recovery of left ventricular function (left ventricular ejection 
      fraction </=55%). RESULTS: The median age, BMI and parity of the study participants 
      was 31.5 (25.5-38.0) years, 28.3 (26.4-29.7) and 3 (2-4) respectively. The 
      prevalence of PPCM was 17.4% (n = 41/236). Multiple pregnancy was the only 
      predictor of PPCM in this study population (OR 4.3 95% CI 1.16-16.05, p = 0.029). 
      Poor outcome at six-months was observed in about 54% of the patients with PPCM (n 
      = 4, 9.8% in NYHA functional class III-IV and n = 22, 53.7% with LVEF <55%). No 
      maternal or foetal mortality was documented. CONCLUSION: PPCM is relatively 
      common in Uganda and is associated with multiple pregnancy. Poor outcomes 
      especially absence of complete recovery of left ventricular function are also 
      common. Large studies to further investigate long-term maternal and foetal 
      outcomes in Uganda are justified.
FAU - Nabbaale, Juliet
AU  - Nabbaale J
AUID- ORCID: 0000-0002-3485-0877
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
FAU - Okello, Emmy
AU  - Okello E
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
FAU - Kibirige, Davis
AU  - Kibirige D
AD  - Department of Medicine, Uganda Martyrs Hospital Lubaga, Kampala, Uganda.
FAU - Ssekitoleko, Isaac
AU  - Ssekitoleko I
AUID- ORCID: 0000-0002-7951-5458
AD  - Statistics Unit, Medical Research Council/Uganda Virus Research Institute and 
      London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, 
      Uganda.
FAU - Isanga, Joseph
AU  - Isanga J
AD  - Department of Obstetrics and Gynaecology, Case Hospital, Kampala, Uganda.
FAU - Karungi, Patience
AU  - Karungi P
AD  - Graduate Entry Medical School, University of Limerick, Limerick, Ireland.
FAU - Sebatta, Elias
AU  - Sebatta E
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
FAU - Zhu, Zhang Wan
AU  - Zhu ZW
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
FAU - Nakimuli, Annettee
AU  - Nakimuli A
AUID- ORCID: 0000-0003-2806-0243
AD  - Department of Obstetrics and Gynaecology, School of Medicine-Makerere University 
      College of Health Sciences, Kampala, Uganda.
FAU - Omagino, John
AU  - Omagino J
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
FAU - Kayima, James
AU  - Kayima J
AD  - Division of Adult Cardiology, Uganda Heart Institute, Kampala, Uganda.
LA  - eng
GR  - D43 TW010132/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20201021
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Black People
MH  - Cardiomyopathies/*physiopathology
MH  - Cohort Studies
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Mortality
MH  - Outcome Assessment, Health Care
MH  - Peripartum Period
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*physiopathology
MH  - Prevalence
MH  - Risk Factors
MH  - Uganda
MH  - Ventricular Dysfunction, Left/*physiopathology
PMC - PMC7577461
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/10/22 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/10/21
CRDT- 2020/10/21 15:36
PHST- 2020/03/15 00:00 [received]
PHST- 2020/10/02 00:00 [accepted]
PHST- 2020/10/21 15:36 [entrez]
PHST- 2020/10/22 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/10/21 00:00 [pmc-release]
AID - PONE-D-20-07456 [pii]
AID - 10.1371/journal.pone.0240837 [doi]
PST - epublish
SO  - PLoS One. 2020 Oct 21;15(10):e0240837. doi: 10.1371/journal.pone.0240837. 
      eCollection 2020.