PMID- 33086712
OWN - NLM
STAT- MEDLINE
DCOM- 20210716
LR  - 20210716
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 11
IP  - 10
DP  - 2020 Oct 19
TI  - Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-beta 
      Production and Antiviral Response.
LID - 10.3390/genes11101226 [doi]
LID - 1226
AB  - TRIM26, a member of the tripartite motif (TRIM) family has been shown to be 
      involved in modulation of innate antiviral response. However, the functional 
      characteristics of porcine TRIM26 (porTRIM26) are unclear. In this study, we used 
      a synthesized antigen peptide to generate a polyclonal antibody against porTRIM26 
      with which to study the expression and function of porTRIM26. We demonstrated 
      that polyinosinic:polycytidylic acid (poly (I:C)) stimulation and viral infection 
      (vesicular stomatitis (VSV) or porcine reproductive and respiratory syndrome 
      virus (PRRSV)) induce expression of porTRIM26, whereas knock-down expression of 
      porTRIM26 promotes interferon (IFN)- production after poly (I:C) stimulation and 
      virus infection (VSV or PRRSV). The importance of the porTRIM26-mediated 
      modulation of the antiviral response was also shown in VSV- or PRRSV-infected 
      cells. In summary, these findings show that porTRIM26 has an inhibitory role in 
      IFN- expression and the antiviral response.
FAU - Huang, Hui
AU  - Huang H
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, 
      China.
FAU - Sharma, Mona
AU  - Sharma M
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Zhang, Yanbing
AU  - Zhang Y
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Li, Chenxi
AU  - Li C
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Liu, Ke
AU  - Liu K
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Wei, Jianchao
AU  - Wei J
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Shao, Donghua
AU  - Shao D
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Li, Beibei
AU  - Li B
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Ma, Zhiyong
AU  - Ma Z
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
FAU - Cao, Ruibing
AU  - Cao R
AD  - College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, 
      China.
FAU - Qiu, Yafeng
AU  - Qiu Y
AD  - Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 
      Shanghai 200241, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201019
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (Antiviral Agents)
RN  - 0 (Tripartite Motif Proteins)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/*pharmacology
MH  - Interferon-beta/*antagonists & inhibitors
MH  - Porcine Reproductive and Respiratory Syndrome/drug 
      therapy/*immunology/metabolism/virology
MH  - Porcine respiratory and reproductive syndrome virus/drug effects/*immunology
MH  - Swine
MH  - Tripartite Motif Proteins/genetics/*metabolism
PMC - PMC7589756
OTO - NOTNLM
OT  - IFN-
OT  - PRRSV
OT  - TRIM26
OT  - VSV
OT  - antiviral response
OT  - poly (I:C)
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/10/23 06:00
MHDA- 2021/07/17 06:00
PMCR- 2020/10/01
CRDT- 2020/10/22 01:02
PHST- 2020/08/29 00:00 [received]
PHST- 2020/10/13 00:00 [revised]
PHST- 2020/10/15 00:00 [accepted]
PHST- 2020/10/22 01:02 [entrez]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/07/17 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - genes11101226 [pii]
AID - genes-11-01226 [pii]
AID - 10.3390/genes11101226 [doi]
PST - epublish
SO  - Genes (Basel). 2020 Oct 19;11(10):1226. doi: 10.3390/genes11101226.