PMID- 33086995
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 2472-5625 (Electronic)
IS  - 2472-5625 (Linking)
VI  - 4
IP  - 2
DP  - 2020 Jul
TI  - Contribution of HLA-DRB1 * 09: 01 allele to development of minocycline induced 
      antineutrophil cytoplasmic antibody (ANCA)-associated cutaneous vasculitis: 
      report of two cases.
PG  - 267-271
LID - 10.1080/24725625.2020.1738983 [doi]
AB  - We report two cases of antineutrophil cytoplasmic antibody (ANCA)-associated 
      vasculitis (AAV) that developed after long-term oral administration of 
      minocycline and consider the contribution of human leukocyte antigen (HLA)-DRB 1 
      * 09: 01 allele to its development. Case 1; A 47-year-old man receiving 
      minocycline for palmoplantar pustulosis for 24 months developed fever, 
      arthralgia, and irregular livedo on the bilateral lower legs. Skin biopsy 
      demonstrated vasculitis, while a blood test showed positivity of myeloperoxidase 
      (MPO)-ANCA. Discontinuation of minocycline and oral administration of 
      prednisolone relieved the symptoms promptly. Case 2; A 53-year-old woman 
      developed reddish-brown livedo reticularis with tenderness on the bilateral lower 
      legs after administration of minocycline to treat palmoplantar pustulosis for 
      24 months. Although skin biopsy did not demonstrate vasculitis, a blood test 
      showed MPO-ANCA positivity. Cessation of minocycline resulted in rapid 
      improvement of the cutaneous lesions and constitutional symptoms. We diagnosed 
      both cases as having Drug-associated ANCA-associated Vasculitis (DAV) caused by 
      minocycline according to the diagnostic criteria proposed by Cluver et al. 
      Further examination revealed the presence of HLA-DRB1 * 09:01 allele in both 
      cases. This allele has been implicated in the genetic background of idiopathic 
      microscopic polyangiitis (MPA) in the Japanese population. Our finding suggests a 
      relationship between the development of MPO-ANCA or DAV caused by minocycline and 
      HLA-DRB1 * 09:01 allele, but will have to confirmed by further studies with 
      larger numbers of patients.
FAU - Kawahara, Hiroyuki
AU  - Kawahara H
AD  - Division of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, 
      Kanazawa, Japan.
FAU - Nakashima, Akikatsu
AU  - Nakashima A
AD  - Division of Nephrology and Rheumatology, Ishikawa Prefectural Central Hospital, 
      Kanazawa, Japan.
FAU - Zoshima, Takeshi
AU  - Zoshima T
AD  - Department of Rheumatology, Graduate School of Medical Science, Kanazawa 
      University, Kanazawa, Japan.
FAU - Kawano, Mitsuhiro
AU  - Kawano M
AD  - Department of Rheumatology, Graduate School of Medical Science, Kanazawa 
      University, Kanazawa, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20200319
PL  - England
TA  - Mod Rheumatol Case Rep
JT  - Modern rheumatology case reports
JID - 101761026
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DRB1 Chains)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - *Alleles
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*diagnosis/*etiology
MH  - Biomarkers
MH  - Biopsy
MH  - Disease Susceptibility
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/blood/*genetics/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minocycline/*adverse effects
OTO - NOTNLM
OT  - HLA-DRB1 * 09: 01
OT  - antineutrophil cytoplasmic antibodies (ANCA)
OT  - cutaneous vasculitis
OT  - drug-associated vasculitis
OT  - minocycline
EDAT- 2020/10/23 06:00
MHDA- 2021/08/27 06:00
CRDT- 2020/10/22 05:25
PHST- 2020/10/22 05:25 [entrez]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
AID - 10.1080/24725625.2020.1738983 [doi]
PST - ppublish
SO  - Mod Rheumatol Case Rep. 2020 Jul;4(2):267-271. doi: 
      10.1080/24725625.2020.1738983. Epub 2020 Mar 19.