PMID- 33087643
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20211129
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 68
IP  - 3
DP  - 2021 Mar 28
TI  - The association between type 1 and 2 diabetes mellitus and the risk of leukemia: 
      a systematic review and meta-analysis of 18 cohort studies.
PG  - 281-289
LID - 10.1507/endocrj.EJ20-0138 [doi]
AB  - Diabetes mellitus (DM) is widely considered to be associated with the risk of 
      diverse cancers; however, the association between DM and the risk of leukemia is 
      still controversial. Thus, a detailed meta-analysis of cohort studies was 
      conducted to elucidate this association. Eligible studies were screened through 
      the electronic searches in PubMed, Web of Science, and Embase from their 
      inception to August 11, 2020. Summary relative risks (RRs) and 95% confidence 
      intervals (CIs) were computed through the random-effects model. Eighteen articles 
      involving 10,516 leukemia cases among a total of 4,094,235 diabetic patients were 
      included in this meta-analysis. Overall, twenty-five RRs were synthesized for 
      type 2 diabetes mellitus (T2DM) and yielded a summary RR of 1.33 (95%CI, 
      1.21-1.47; p < 0.001). For type 1 diabetes mellitus (T1DM), 7 RRs were combined, 
      however, the pooled RR was insignificant (RR, 1.08; 95%CI, 0.87-1.34; p = 0.48). 
      Interestingly, the summary RR for East Asia (RR, 1.83, 95%CI, 1.63-2.06) was 
      significantly higher than that for Europe (RR, 1.11, 95%CI, 1.06-1.15), Western 
      Asia (RR, 1.40, 95%CI, 1.25-1.54), North America (RR, 1.14, 95%CI, 1.08-1.20), 
      and Australia (RR, 1.47, 95%CI, 1.25-1.71). Moreover, we found that patients with 
      a shorter T2DM duration (1-5 years) had a higher risk of leukemia compared to 
      those with a longer duration (5.1-10 years). Overall, this meta-analysis suggests 
      there is a moderately increased risk of leukemia among T2DM patients, but not in 
      T1DM patients. Further investigation is warranted.
FAU - Yan, Pengfei
AU  - Yan P
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      Wuhan 430071, China.
FAU - Wang, Yongbo
AU  - Wang Y
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan 430071, China.
FAU - Fu, Tao
AU  - Fu T
AD  - Department of Gastrointestinal Surgery II, Renmin Hospital, Wuhan University, 
      Wuhan 430060, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Statistics and Management, School of Management, Wuhan Institute of 
      Technology, Wuhan 430205, China.
FAU - Zhang, Zhi-Jiang
AU  - Zhang ZJ
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      Wuhan 430071, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20201020
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
SB  - IM
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*epidemiology
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Humans
MH  - Leukemia/*epidemiology
OTO - NOTNLM
OT  - Leukemia
OT  - Meta-analysis
OT  - Risk
OT  - Type 1 diabetes mellitus
OT  - Type 2 diabetes mellitus
EDAT- 2020/10/23 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/10/22 05:29
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/10/22 05:29 [entrez]
AID - 10.1507/endocrj.EJ20-0138 [doi]
PST - ppublish
SO  - Endocr J. 2021 Mar 28;68(3):281-289. doi: 10.1507/endocrj.EJ20-0138. Epub 2020 
      Oct 20.