PMID- 33087644
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 68
IP  - 2
DP  - 2021 Feb 28
TI  - Serum osteocalcin is inversely associated with lower extremity atherosclerotic 
      disease in Chinese patients with type 2 diabetes mellitus.
PG  - 137-144
LID - 10.1507/endocrj.EJ20-0186 [doi]
AB  - Serum osteocalcin (OCN) is closely related to metabolic risk factors, and the 
      relationship between OCN and atherosclerosis has been investigated. However, it 
      is still controversial. Herein, we explored the potential correlation between 
      serum total OCN and lower extremity atherosclerotic disease (LEAD) in 326 
      hospitalized Chinese patients with type 2 diabetes mellitus (T2DM). Femoral 
      intima-media thickness (F-IMT) and lower limb atherosclerotic plaque were 
      assessed through color Doppler ultrasound. Subjects with LEAD had significantly 
      lower serum OCN levels compared with those without LEAD (14.54 [14.10-14.89] 
      ng/mL versus 16.79 [15.86-18.04] ng/mL, p < 0.001). Spearman's correlation 
      analysis revealed that serum OCN levels were positively associated with high 
      density lipoprotein cholesterol (HDL-C) and negatively associated with fasting 
      plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), hemoglobin A1c 
      (HbA1c), waist-to-hip ratio (WHR) and F-IMT. Multiple logistic analysis revealed 
      that OCN (OR 0.938, 95% confidence interval (CI 0.933-0.950, p = 0.003) and 
      glomerular filtration rate (GFR) (OR 0.990, 95% CI 0.985-0.996, p = 0.003) were 
      independently and inversely associated with LEAD, while age (OR 1.140, 95% CI 
      1.127-1.148, p < 0.001), diabetes duration (OR 1.068, 95% CI 1.039-1.080, p < 
      0.005) and uric acid (UA) (OR 1.005, 95% CI 1.002-1.007, p = 0.032) were 
      independently and positively associated with LEAD. Additionally, multiple linear 
      regression analysis revealed that serum OCN levels were negatively associated 
      with F-IMT (standardized beta = -0.180, p = 0.002). In Chinese patients with T2DM, 
      serum OCN levels were independently and inversely correlated with LEAD.
FAU - Lv, Qihuan
AU  - Lv Q
AD  - Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Anhui, 
      230001, People's Republic of China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Anhui, 
      230001, People's Republic of China.
FAU - Liu, Jiongjiong
AU  - Liu J
AD  - Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Anhui, 
      230001, People's Republic of China.
FAU - Kang, Dongmei
AU  - Kang D
AD  - Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Anhui, 
      230001, People's Republic of China.
FAU - Zhang, Hongyu
AU  - Zhang H
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Shandong, 250012, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20201020
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/blood/*complications/diagnostic imaging
MH  - China
MH  - Diabetes Mellitus, Type 2/blood/*complications/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/*blood
MH  - Ultrasonography, Doppler, Color
OTO - NOTNLM
OT  - Femoral intima-media thickness
OT  - Lower extremity atherosclerotic disease
OT  - Osteocalcin
OT  - Type 2 diabetes mellitus
EDAT- 2020/10/23 06:00
MHDA- 2021/11/03 06:00
CRDT- 2020/10/22 05:29
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2020/10/22 05:29 [entrez]
AID - 10.1507/endocrj.EJ20-0186 [doi]
PST - ppublish
SO  - Endocr J. 2021 Feb 28;68(2):137-144. doi: 10.1507/endocrj.EJ20-0186. Epub 2020 
      Oct 20.