PMID- 33088293
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 1735-1995 (Print)
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 25
DP  - 2020
TI  - Association of microRNA gene polymorphisms with Type 2 diabetes mellitus: A 
      systematic review and meta-analysis.
PG  - 56
LID - 10.4103/jrms.JRMS_751_19 [doi]
LID - 56
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with growing 
      prevalence and increasing economic burden. Based on the role of genetics and 
      epigenetic factors on T2DM, we aimed to carry a systematic review and 
      meta-analysis for all miRNA gene polymorphisms and risk of T2DM. MATERIALS AND 
      METHODS: A computerized literature search was carried out on PubMed, Web of 
      Science, Scopus, Embase, as well as references of relevant review/meta-analysis. 
      Key search terms were "Diabetes Mellitus, Type 2," "MicroRNAs," and 
      "Polymorphism, Single Nucleotide." All types of observational studies from 
      January 1, 1992, to November 30, 2019, were included, without language 
      restriction. Data analysis was performed using R programming language (3.5.2). 
      Level of heterogeneity was obtained by Cochran's Q test (P < 0.05), and subgroup 
      analysis was performed based on ethnicity. RESULTS: Thirty-two polymorphisms from 
      fifteen articles were included. Meta-analysis was carried out based on minor 
      allele frequencies. Seven studies with 2193 cases and 3963 controls were included 
      for rs2910164 polymorphism. In subgroup analysis, there were significant results 
      in Caucasian population in dominant model (odds ratio [OR] =1.12; 95% confidence 
      interval [CI]: 0.83-1.51), homozygote model (OR = 1.78; 95% CI: 1.06-3.00), 
      heterozygote model (OR = 1.77; 95% CI: 1.03-3.05), and recessive model (OR = 
      1.78; 95% CI: 1.07-2.96). Four studies with 2085 cases and 1933 controls were 
      included for rs895819 polymorphism. Overall, there was no significant result for 
      association with rs895819, but subgroup analysis revealed that minor allele 
      significantly decreased the risk of T2DM in Caucasians by recessive model (OR = 
      0.34; 95% CI: 0.18-0.66), dominant model (OR = 0.70; 95% CI: 0.52-0.94), 
      homozygote model (OR = 0.32; 95% CI: 0.16-0.62), heterozygote model (OR = 0.37; 
      95% CI: 0.19-0.74), allelic model (OR = 0.67; 95% CI: 0.52-0.85). CONCLUSION: The 
      minor allele of rs2910164 may increase the risk of T2DM by leading to lower level 
      of miR-146a. In contrast, minor allele of rs895819 may decrease the risk of T2DM 
      by leading to higher level of miR-27a.
CI  - Copyright: (c) 2020 Journal of Research in Medical Sciences.
FAU - Gholami, Morteza
AU  - Gholami M
AD  - Metabolic Disorders Research Center, Endocrinology and Metabolism 
      Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
AD  - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Asgarbeik, Saeedeh
AU  - Asgarbeik S
AD  - Metabolic Disorders Research Center, Endocrinology and Metabolism 
      Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Razi, Farideh
AU  - Razi F
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Esfahani, Ensieh Nasli
AU  - Esfahani EN
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Zoughi, Marzieh
AU  - Zoughi M
AD  - Metabolic Disorders Research Center, Endocrinology and Metabolism 
      Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Vahidi, Aida
AU  - Vahidi A
AD  - Metabolic Disorders Research Center, Endocrinology and Metabolism 
      Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Larijani, Bagher
AU  - Larijani B
AD  - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Amoli, Mahsa Mohammad
AU  - Amoli MM
AD  - Metabolic Disorders Research Center, Endocrinology and Metabolism 
      Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200630
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC7554443
OTO - NOTNLM
OT  - MicroRNAs
OT  - Type 2 diabetes
OT  - polymorphism
COIS- There are no conflicts of interest.
EDAT- 2020/10/23 06:00
MHDA- 2020/10/23 06:01
PMCR- 2020/06/30
CRDT- 2020/10/22 05:36
PHST- 2019/11/04 00:00 [received]
PHST- 2019/12/22 00:00 [revised]
PHST- 2020/02/26 00:00 [accepted]
PHST- 2020/10/22 05:36 [entrez]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2020/10/23 06:01 [medline]
PHST- 2020/06/30 00:00 [pmc-release]
AID - JRMS-25-56 [pii]
AID - 10.4103/jrms.JRMS_751_19 [doi]
PST - epublish
SO  - J Res Med Sci. 2020 Jun 30;25:56. doi: 10.4103/jrms.JRMS_751_19. eCollection 
      2020.