PMID- 33090488
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
DP  - 2020 Oct 8
TI  - Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-kappaB pathway.
LID - 10.1002/jcp.30083 [doi]
AB  - The aim of this study was to investigate the role of scoparone (SCO) in hepatic 
      fibrosis. For this, we conducted in vivo and in vitro experiments. In vivo rats 
      that were divided into six groups, control, carbon tetrachloride, and colchicine, 
      as well as SCO groups, SCO50, SCO100, and SCO200 treated with 50, 100, and 
      200 mg/kg SCO doses, respectively. Furthermore, SCO was shown to inhibit 
      Toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-kappaB; TLR-4/NF-kappaB) signals 
      by inhibiting TLR-4, which in turn downregulates the expression of MyD88, 
      promotes NF-kappaB inhibitor-alpha, NF-kappaB inhibitor-beta, and NF-kappaB inhibitor-epsilon activation, 
      while inhibiting NF-kappaB inhibitor-zeta. Subsequently, the decrease of phosphorylation 
      of nuclear factor-kappaB levels leads to the downregulation of the downstream 
      inflammatory factors' tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 
      and IL-1 beta, thus weakening hepatic fibrosis. Notably, the SCO200 treated group 
      presented the most significant improvement. Hence, we conclude that SCO 
      alleviates hepatic fibrosis by inhibiting TLR-4/NF-kappaB signals.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Gao, Ya
AU  - Gao Y
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Xi, Boting
AU  - Xi B
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Li, Jiani
AU  - Li J
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Li, Zimeng
AU  - Li Z
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Xu, Jie
AU  - Xu J
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Zhong, Mingli
AU  - Zhong M
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Xu, Qiongmei
AU  - Xu Q
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Lian, Yuanyu
AU  - Lian Y
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Wei, Riming
AU  - Wei R
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Wang, Liping
AU  - Wang L
AUID- ORCID: 0000-0001-6372-5939
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
FAU - Cao, Houkang
AU  - Cao H
AD  - College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
FAU - Jin, Ling
AU  - Jin L
AD  - College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
FAU - Zhang, Kefeng
AU  - Zhang K
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
AD  - College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
FAU - Dong, Jianghui
AU  - Dong J
AUID- ORCID: 0000-0001-9754-7683
AD  - College of Pharmacy, Guilin Medical University, Guilin, Guangxi, China.
LA  - eng
GR  - 2017GXNSFAA198218/National Science Foundation of Guangxi Province of China/
GR  - 2017GXNSFAA198326/National Science Foundation of Guangxi Province of China/
GR  - 2018GXNSFAA281040/National Science Foundation of Guangxi Province of China/
GR  - Special funding for 2017 Guangxi BaGui Scholars/
GR  - 81660104/National Natural Science Foundation of China/
GR  - 81760114/National Natural Science Foundation of China/
GR  - 81860673/National Natural Science Foundation of China/
GR  - 81960779/National Natural Science Foundation of China/
GR  - 62061012/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20201008
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
SB  - IM
OTO - NOTNLM
OT  - Toll-like receptor-4/nuclear factor kappa-B
OT  - hepatic fibrosis
OT  - phosphorylation of nuclear factor-kappaB
OT  - scoparone
EDAT- 2020/10/23 06:00
MHDA- 2020/10/23 06:00
CRDT- 2020/10/22 12:19
PHST- 2020/01/09 00:00 [received]
PHST- 2020/09/07 00:00 [revised]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2020/10/22 12:19 [entrez]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
AID - 10.1002/jcp.30083 [doi]
PST - aheadofprint
SO  - J Cell Physiol. 2020 Oct 8. doi: 10.1002/jcp.30083.