PMID- 33091646
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 146
DP  - 2021 Feb
TI  - VNS Stopping Anti-NMDA Receptor Encephalitis-Triggered Nonconvulsive Status 
      Epilepticus.
PG  - 364-366.e2
LID - S1878-8750(20)32268-3 [pii]
LID - 10.1016/j.wneu.2020.10.076 [doi]
AB  - BACKGROUND: Anti-NMDA receptor encephalitis (ANRE) is a rare autoimmune 
      neurologic disorder characterized by encephalitis and a constellational of 
      symptoms, including seizures, psychiatric disturbances, autonomic instability, 
      and respiratory insufficiency. It is caused by the anti-NMDA receptor antibody. 
      The most common etiologies for ANRE include malignancy and infection. Ovarian 
      teratoma is the most commonly associated malignancy. CASE DESCRIPTION: We 
      describe the first reported case to our knowledge of ovarian teratoma causing 
      ANRE resulting in nonconvulsive status epilepticus (NCSE), which was terminated 
      with vagus nerve stimulation (VNS). CONCLUSIONS: This case report provides a 
      temporal correlation suggesting that VNS significantly altered the natural 
      history of this patient's NCSE-ANRE. As more data are collected, and the VNS 
      treatment modality more liberally used to treat NCSE, especially in the situation 
      of ANRE, stronger layers of evidence will emerge to fill the gaps of 
      understanding beyond this case report.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Dhaliwal, Joravar
AU  - Dhaliwal J
AD  - Department of Neurosurgery, Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA. Electronic address: joravar.dhaliwal@osumc.edu.
FAU - Ganguly, Ranjit
AU  - Ganguly R
AD  - Department of Neurosurgery, Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
FAU - Mindel, Jesse
AU  - Mindel J
AD  - Department of Neurology, Ohio State University Wexner Medical Center, Columbus, 
      Ohio, USA.
FAU - Krishna, Vibhor
AU  - Krishna V
AD  - Department of Neurosurgery, Ohio State University Wexner Medical Center, 
      Columbus, Ohio, USA.
LA  - eng
PT  - Case Reports
DEP - 20201019
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
RN  - Teratoma, Ovarian
SB  - IM
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*etiology
MH  - Female
MH  - Humans
MH  - Ovarian Neoplasms/*complications
MH  - Status Epilepticus/*etiology/*therapy
MH  - Teratoma/*complications
MH  - Treatment Outcome
MH  - *Vagus Nerve Stimulation
OTO - NOTNLM
OT  - Epilepsy
OT  - Functional neurosurgery
OT  - Status epilepticus
OT  - VNS
EDAT- 2020/10/23 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/22 20:12
PHST- 2020/07/27 00:00 [received]
PHST- 2020/10/14 00:00 [accepted]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/22 20:12 [entrez]
AID - S1878-8750(20)32268-3 [pii]
AID - 10.1016/j.wneu.2020.10.076 [doi]
PST - ppublish
SO  - World Neurosurg. 2021 Feb;146:364-366.e2. doi: 10.1016/j.wneu.2020.10.076. Epub 
      2020 Oct 19.