PMID- 33091773
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20211109
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 208
DP  - 2021 Jan 15
TI  - Polyfluoroalkyl chemicals and the risk of kidney stones in US adults: A 
      population-based study.
PG  - 111497
LID - S0147-6513(20)31334-8 [pii]
LID - 10.1016/j.ecoenv.2020.111497 [doi]
AB  - The potential nephrotoxicity of polyfluoroalkyl chemicals (PFCs) have received 
      extensive attention. However, the relationship between PFCs and the risk of 
      kidney stones remain unclear. This study aimed to examine the level of PFCs in 
      the US population and its relationship with the risk of kidney stones. We 
      investigated the serum levels of six PFCs in 8453 adult participants (>/=20 years) 
      from the National Health and Nutrition Examination Survey (NHANES) between 2007 
      and 2016, including perfluorodecanoic acid (PFDE), perfluorohexane sulfonic acid 
      (PFHS), 2-(N-methyl-perfluorooctane sulfonamido) acetate (MPAH), 
      perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUA), and 
      perfluorododecanoic acid (PFDO). Logistic regression model was used to evaluate 
      the correlation between PFCs and kidney stones. Of the 8453 participants, 787 
      self-reported a history of kidney stones. After adjusting for gender, age, race, 
      education, marital status, body mass index (BMI), hypertension, diabetes and 
      estimated glomerular filtration rate (eGFR), we found that total PFCs and PFHS 
      were positively correlated with the risk of kidney stones. Compared with the 
      lowest tertile, the odds ratios with 95% confidence intervals (CI) with 
      increasing tertiles were 1.30 (95% CI,1.08-1.59, p = 0.007) and 1.25 (95 
      CI%,1.00-1.52, p = 0.024) for total PFCs and 1.24 (95 CI%,1.03-1.51, p = 0.032), 
      and 1.35 (95 CI,1.10-1.68, p = 0.005) for PFHS. Our study shows that total PFCs 
      and PFHS were associated with an increased risk of kidney stones.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Mao, Weipu
AU  - Mao W
AD  - Department of Urology, People's Hospital of Putuo District, Shanghai 200060, 
      China; Department of Urology, Affiliated Zhongda Hospital of Southeast 
      University, Nanjing 210009, China.
FAU - Hu, Qiang
AU  - Hu Q
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China.
FAU - Chen, Saisai
AU  - Chen S
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China.
FAU - Luo, Ming
AU  - Luo M
AD  - Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai 200072, China.
FAU - Zhang, Ziwei
AU  - Zhang Z
AD  - Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, 
      Tongji University, Shanghai 200072, China.
FAU - Geng, Jiang
AU  - Geng J
AD  - Department of Urology, People's Hospital of Putuo District, Shanghai 200060, 
      China; Department of Urology, Shanghai Tenth People's Hospital, School of 
      Medicine, Tongji University, Shanghai 200072, China.
FAU - Wu, Jianping
AU  - Wu J
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China.
FAU - Xu, Bin
AU  - Xu B
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China. Electronic address: njxb1982@126.com.
FAU - Chen, Ming
AU  - Chen M
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Nanjing 210009, China. Electronic address: mingchenseu@126.com.
LA  - eng
PT  - Journal Article
DEP - 20201019
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 355-46-4 (perfluorohexanesulfonic acid)
SB  - IM
CIN - J Urol. 2021 May;205(5):1509-1511. PMID: 33629872
MH  - Adult
MH  - Environmental Pollutants/*adverse effects/blood
MH  - Female
MH  - Fluorocarbons/*adverse effects/blood
MH  - Health Surveys
MH  - Humans
MH  - Kidney Calculi/blood/*chemically induced/*epidemiology
MH  - Male
MH  - Odds Ratio
MH  - Risk
MH  - Sulfonic Acids/adverse effects/blood
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Cross-sectional survey
OT  - Kidney stone
OT  - National health and nutrition examination survey
OT  - Perfluorohexane sulfonic acid
OT  - Polyfluoroalkyl chemicals
EDAT- 2020/10/23 06:00
MHDA- 2021/01/08 06:00
CRDT- 2020/10/22 20:16
PHST- 2020/07/18 00:00 [received]
PHST- 2020/09/29 00:00 [revised]
PHST- 2020/10/10 00:00 [accepted]
PHST- 2020/10/23 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/10/22 20:16 [entrez]
AID - S0147-6513(20)31334-8 [pii]
AID - 10.1016/j.ecoenv.2020.111497 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Jan 15;208:111497. doi: 
      10.1016/j.ecoenv.2020.111497. Epub 2020 Oct 19.