PMID- 33092193
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20210112
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 20
DP  - 2020 Oct 20
TI  - Serum Concentrations of Selected Organochlorines in Pregnant Women and 
      Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural 
      Settings in Cambodia.
LID - 10.3390/ijerph17207652 [doi]
LID - 7652
AB  - We conducted a cross-sectional study among 194 pregnant women from two low-income 
      settings in Cambodia. The inclusion period lasted from October 2015 through 
      December 2017. Maternal serum samples were analyzed for persistent organic 
      pollutants (POPs). The aim was to study potential effects on birth outcomes. We 
      found low levels of polychlorinated biphenyls (PCBs) and organochlorine 
      pesticides (OCP), except for heptachlors, beta-hexachlorocyclohexane (HCH), 
      heptachlor epoxide, and p,p'-DDE. There were few differences between the two 
      study locations. However, the women from the poorest areas had significantly 
      higher concentrations of p,p'-DDE (p < 0.001) and hexachlorobenzene (HCB) (p = 
      0.002). The maternal factors associated with exposure were parity, age, 
      residential area, and educational level. Despite low maternal levels of 
      polychlorinated biphenyls, we found significant negative associations between the 
      PCB congeners 99 (95% CI: -2.51 to -0.07), 138 (95% CI: -1.28 to -0.32), and 153 
      (95% CI: -1.06 to -0.05) and gestational age. Further, there were significant 
      negative associations between gestational age, birth length, and maternal levels 
      of o,p'-DDE. Moreover, o,p'-DDD had positive associations with birth weight, and 
      both p,p'-DDD and o,p'-DDE were positively associated with the baby's ponderal 
      index. The poorest population had higher exposure and less favorable outcomes.
FAU - Steinholt, Margit
AU  - Steinholt M
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
AD  - Helgelandssykehuset, 8801 Sandnessjoen, Norway.
FAU - Xu, Shanshan
AU  - Xu S
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
FAU - Ha, Sam Ol
AU  - Ha SO
AD  - Trauma Care Foundation, Battambang, Cambodia.
FAU - Phi, Duong Trong
AU  - Phi DT
AD  - Department of Environment and School Health, Nha Trang Pasteur Institutte, Nha 
      Trang, Khanh Hoa 650000, Vietnam.
FAU - Odland, Maria Lisa
AU  - Odland ML
AD  - Institute of Applied Health Research, University of Birmingham, Birmingham 
      B152TT, UK.
FAU - Odland, Jon Oyvind
AU  - Odland JO
AD  - Department of Public Health and Nursing, Norwegian University of Science and 
      Technology, 7491 Trondheim, Norway.
AD  - Department of General Hygiene I.M. Sechenov First Moscow State Medical University 
      (Sechenov University), Trubetskaya str., 8-2, 119992 Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201020
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cambodia
MH  - Cross-Sectional Studies
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Infant, Newborn
MH  - Male
MH  - *Pesticides/analysis
MH  - *Polychlorinated Biphenyls
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Pregnant Women
PMC - PMC7589876
OTO - NOTNLM
OT  - low-resource settings
OT  - neonatal health
OT  - organochlorine pesticides
OT  - polychlorinated biphenyls
OT  - pregnancy outcomes
OT  - stunting
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/24 06:00
MHDA- 2021/01/13 06:00
PMCR- 2020/10/01
CRDT- 2020/10/23 01:01
PHST- 2020/08/25 00:00 [received]
PHST- 2020/10/16 00:00 [revised]
PHST- 2020/10/17 00:00 [accepted]
PHST- 2020/10/23 01:01 [entrez]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - ijerph17207652 [pii]
AID - ijerph-17-07652 [pii]
AID - 10.3390/ijerph17207652 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Oct 20;17(20):7652. doi: 
      10.3390/ijerph17207652.