PMID- 33092195
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201030
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 10
DP  - 2020 Oct 20
TI  - Belching in Gastroesophageal Reflux Disease: Literature Review.
LID - 10.3390/jcm9103360 [doi]
LID - 3360
AB  - Belching is a common phenomenon. However, it becomes bothersome if excessive. 
      Impedance-pH monitoring can classify the belching into two types: gastric 
      belching and supragastric belching (SGB). The former is a physiological mechanism 
      to vent swallowed air from the stomach, whereas the latter is a behavioral 
      disorder. Gastroesophageal reflux disease (GERD) is the most relevant condition 
      in both types of belching. Recent findings have raised awareness that excessive 
      SGB possibly sheds light on the pathogenesis of a part of proton pump inhibitor 
      (PPI) refractoriness in GERD. SGB could cause typical reflux symptoms such as 
      heartburn, regurgitation or chest pain in two ways: SGB-induced gastroesophageal 
      reflux or SGB-induced esophageal distension. In PPI-refractory GERD, it is 
      important to detect hidden SGB as a cause of reflux symptoms since SGB requires 
      psychological treatment instead of high dose PPIs or pain modulators. In the case 
      of PPI-refractory GERD with excessive SGB, recent studies imply that the 
      combination of a psychological approach and conventional treatment can improve 
      treatment outcome.
FAU - Sawada, Akinari
AU  - Sawada A
AUID- ORCID: 0000-0002-0590-3693
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, Osaka 545-8585, Japan.
FAU - Fujiwara, Yasuhiro
AU  - Fujiwara Y
AD  - Department of Gastroenterology, Osaka City University Graduate School of 
      Medicine, Osaka 545-8585, Japan.
FAU - Sifrim, Daniel
AU  - Sifrim D
AD  - Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The 
      London School of Medicine and Dentistry, Queen Mary University of London, London 
      E1 2AJ, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201020
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7590068
OTO - NOTNLM
OT  - epidemiology
OT  - functional heartburn
OT  - gastric belching
OT  - gastroesophageal reflux disease
OT  - impedance-pH monitoring
OT  - non-erosive reflux disease
OT  - reflux hypersensitivity
OT  - supragastric belching
COIS- All the authors declare no conflict of interest with this review.
EDAT- 2020/10/24 06:00
MHDA- 2020/10/24 06:01
PMCR- 2020/10/20
CRDT- 2020/10/23 01:01
PHST- 2020/10/04 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/10/23 01:01 [entrez]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2020/10/24 06:01 [medline]
PHST- 2020/10/20 00:00 [pmc-release]
AID - jcm9103360 [pii]
AID - jcm-09-03360 [pii]
AID - 10.3390/jcm9103360 [doi]
PST - epublish
SO  - J Clin Med. 2020 Oct 20;9(10):3360. doi: 10.3390/jcm9103360.