PMID- 33092261
OWN - NLM
STAT- MEDLINE
DCOM- 20210325
LR  - 20240330
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 20
DP  - 2020 Oct 20
TI  - The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance 
      to Autophagy-Independent Effects.
LID - 10.3390/molecules25204839 [doi]
LID - 4839
AB  - The present review focuses on the multi-faceted effects of curcumin on the 
      neurobiology glioblastoma multiforme (GBM), with a special emphasis on autophagy 
      (ATG)-dependent molecular pathways activated by such a natural polyphenol. This 
      is consistent with the effects of curcumin in a variety of experimental models of 
      neurodegeneration, where the molecular events partially overlap with GBM. In 
      fact, curcumin broadly affects various signaling pathways, which are similarly 
      affected in cell degeneration and cell differentiation. The antitumoral effects 
      of curcumin include growth inhibition, cell cycle arrest, anti-migration and 
      anti-invasion, as well as chemo- and radio-sensitizing activity. Remarkably, most 
      of these effects rely on mammalian target of rapamycin (mTOR)-dependent ATG 
      induction. In addition, curcumin targets undifferentiated and highly tumorigenic 
      GBM cancer stem cells (GSCs). When rescuing ATG with curcumin, the tumorigenic 
      feature of GSCs is suppressed, thus counteracting GBM establishment and growth. 
      It is noteworthy that targeting GSCs may also help overcome therapeutic 
      resistance and reduce tumor relapse, which may lead to a significant improvement 
      of GBM prognosis. The present review focuses on the multi-faceted effects of 
      curcumin on GBM neurobiology, which represents an extension to its 
      neuroprotective efficacy.
FAU - Ryskalin, Larisa
AU  - Ryskalin L
AUID- ORCID: 0000-0003-3150-1863
AD  - Department of Translational Research and New Technologies in Medicine and 
      Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
FAU - Biagioni, Francesca
AU  - Biagioni F
AUID- ORCID: 0000-0003-3566-4889
AD  - I.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, Italy.
FAU - Busceti, Carla L
AU  - Busceti CL
AD  - I.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, Italy.
FAU - Lazzeri, Gloria
AU  - Lazzeri G
AD  - Department of Translational Research and New Technologies in Medicine and 
      Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
FAU - Frati, Alessandro
AU  - Frati A
AD  - I.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, Italy.
FAU - Fornai, Francesco
AU  - Fornai F
AD  - Department of Translational Research and New Technologies in Medicine and 
      Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.
AD  - I.R.C.C.S. Neuromed, Via Atinense 18, 86077 Pozzilli, Italy.
LA  - eng
GR  - Ricerca Corrente 2020/Ministero della Salute/
PT  - Journal Article
PT  - Review
DEP - 20201020
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Autophagy/*drug effects
MH  - Cell Differentiation/drug effects
MH  - Cell Movement/drug effects
MH  - Cell Proliferation/*drug effects
MH  - Curcumin/*pharmacology
MH  - Glioblastoma/*drug therapy/pathology
MH  - Humans
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Neoplastic Stem Cells/drug effects
MH  - Signal Transduction/drug effects
PMC - PMC7587955
OTO - NOTNLM
OT  - anti-cancer effects
OT  - autophagy
OT  - curcuma longa
OT  - glioblastoma stem-like cells
OT  - natural polyphenols
OT  - neuroprotection
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/24 06:00
MHDA- 2021/03/26 06:00
PMCR- 2020/10/20
CRDT- 2020/10/23 01:01
PHST- 2020/09/25 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/10/23 01:01 [entrez]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/03/26 06:00 [medline]
PHST- 2020/10/20 00:00 [pmc-release]
AID - molecules25204839 [pii]
AID - molecules-25-04839 [pii]
AID - 10.3390/molecules25204839 [doi]
PST - epublish
SO  - Molecules. 2020 Oct 20;25(20):4839. doi: 10.3390/molecules25204839.