PMID- 33092550
OWN - NLM
STAT- MEDLINE
DCOM- 20210107
LR  - 20210107
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 21
IP  - Suppl 1
DP  - 2020 Oct 22
TI  - Understanding the molecular association between hyperkalemia and lung squamous 
      cell carcinomas.
PG  - 176
LID - 10.1186/s12881-020-01099-7 [doi]
LID - 176
AB  - BACKGROUND: Previous studies indicated a strong association between hyperkalemia 
      and lung squamous cell carcinomas (LSCC). However, the underlying mechanism is 
      not fully understood so far. METHODS: Literature-based data mining was conducted 
      to identify genes, molecule, and cell processes linked to both hyperkalemia and 
      LSCC. Pathway analysis was performed to explore the interactive network, 
      common-target network, and common-regulator network for both disorders. Then, a 
      mega-analysis using 11 independent LSCC RNA expression datasets (358 LSCCs and 
      278 healthy controls) was performed to test the hypothesis that genes influencing 
      hyperkalemia may also play roles in LSCC. RESULTS: There was a significant 
      overlap between the genes implicated with both diseases (20 genes, 
      p-value = 4.98e-15), which counts for 16% of all hyperkalemia genes (125 genes). 
      Network analysis identified 12 molecules as common targets for hyperkalemia and 
      LSCC, and 19 molecules as common regulators. Moreover, 19 molecules were 
      identified within an interactive network, through which hyperkalemia and LSCC 
      could exert influence on each other. In addition, meta-analysis identified one 
      hyperkalemia promoter, SPP1, as a novel contributor for LSCC (LFC = 2.64; 
      p-value = 2.81e-6). MLR analysis suggests geographical region as an influential 
      factor for the expression levels of SPP1 in LSCC patients (p value = 0.036, 
      0.054). CONCLUSION: Our results showed that there was a common molecular basis 
      for the pathology of both hyperkalemia and LSCC, and that genes promoting 
      hyperkalemia might also play roles in the development of LSCC. However, this 
      study did not suggest hypercalcemia as a casual factor for LSCC.
FAU - Meng, Xianping
AU  - Meng X
AD  - Department of Radiology, Jiangyin People's Hospital, Jiangyin, 214400, Jiangsu 
      Province, China.
FAU - Lu, Hongyan
AU  - Lu H
AD  - Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of 
      Southeast University Medical College, Jiangyin, 214400, Jiangsu, China.
FAU - Jiang, Xia
AU  - Jiang X
AD  - Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of 
      Southeast University Medical College, Jiangyin, 214400, Jiangsu, China.
FAU - Huang, Bin
AU  - Huang B
AD  - Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of 
      Southeast University Medical College, Jiangyin, 214400, Jiangsu, China.
FAU - Wu, Song
AU  - Wu S
AD  - Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of 
      Southeast University Medical College, Jiangyin, 214400, Jiangsu, China.
FAU - Yu, Guiping
AU  - Yu G
AUID- ORCID: 0000-0003-0418-5340
AD  - Department of Cardiothoracic Surgery, The affiliated Jiangyin Hospital of 
      Southeast University Medical College, Jiangyin, 214400, Jiangsu, China. 
      g.yu@gousinfo.com.
FAU - Cao, Hongbao
AU  - Cao H
AD  - Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi 
      Medical University, Taiyuan, 030001, Shanxi Province, China. 
      caohon2010@gmail.com.
AD  - Department of Genomics Research, RD Solutions, Elsevier Inc, Rockville, MD, 
      20852, USA. caohon2010@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20201022
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (SPP1 protein, human)
RN  - 106441-73-0 (Osteopontin)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/pathology
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Predisposition to Disease/genetics
MH  - Geography
MH  - Humans
MH  - Hyperkalemia/*genetics/pathology
MH  - Lung Neoplasms/*genetics/pathology
MH  - Osteopontin/*genetics
MH  - Potassium/blood
PMC - PMC7579872
OTO - NOTNLM
OT  - Hyperkalemia
OT  - Lung squamous cell carcinomas
OT  - Mega-analysis
OT  - Multiple linear regression analysis
OT  - Pathway analysis
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/24 06:00
MHDA- 2021/01/08 06:00
PMCR- 2020/10/22
CRDT- 2020/10/23 05:31
PHST- 2020/07/16 00:00 [received]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/10/23 05:31 [entrez]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/01/08 06:00 [medline]
PHST- 2020/10/22 00:00 [pmc-release]
AID - 10.1186/s12881-020-01099-7 [pii]
AID - 1099 [pii]
AID - 10.1186/s12881-020-01099-7 [doi]
PST - epublish
SO  - BMC Med Genet. 2020 Oct 22;21(Suppl 1):176. doi: 10.1186/s12881-020-01099-7.