PMID- 33094090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2196-5471 (Print)
IS  - 2196-5471 (Electronic)
IS  - 2196-5471 (Linking)
VI  - 6
IP  - 3
DP  - 2019 Sep
TI  - Epstein-Barr Virus and the Human Leukocyte Antigen Complex.
PG  - 175-181
LID - 10.1007/s40588-019-00120-9 [doi]
AB  - PURPOSE: While most adults are infected Epstein-Barr virus (EBV), 3-5% remain 
      uninfected. The human leukocyte antigen (HLA) complex, which controls many 
      pathogens, may influence infection and disease associated with EBV. RECENT 
      FINDINGS: Numerous EBV proteins and miRNAs down-regulate HLA class I and II 
      expression on the cell surface. HLA class II functions as a receptor for EBV 
      entry into B cells. Specific HLA class II alleles correlate with the 
      susceptibility of B cells to EBV infection in vitro and with EBV seropositivity 
      or seronegativity of humans. HLA class I polymorphisms correlate with development 
      and severity of EBV infectious mononucleosis and with the risk of several 
      virus-associated malignancies including nasopharyngeal carcinoma, Hodgkin 
      lymphoma, and post-transplant lymphoproliferative disease. SIGNIFICANCE: These 
      findings indicate that while EBV has evolved to use MHC class II as a receptor 
      for virus entry, polymorphisms in MHC class II and class I influence virus 
      infection and disease.
FAU - Li, Qingxue
AU  - Li Q
AD  - Medical Virology Section, Laboratory of Infectious Diseases, National Institute 
      of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
FAU - Cohen, Jeffrey I
AU  - Cohen JI
AD  - Medical Virology Section, Laboratory of Infectious Diseases, National Institute 
      of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
LA  - eng
GR  - Z01 AI000913/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20190708
PL  - Switzerland
TA  - Curr Clin Microbiol Rep
JT  - Current clinical microbiology reports
JID - 101642669
PMC - PMC7577584
MID - NIHMS1533954
OTO - NOTNLM
OT  - Epstein-Barr
OT  - HLA
OT  - Hodgkin lymphoma
OT  - MHC
OT  - infectious mononucleosis
OT  - nasopharyngeal carcinoma
COIS- Conflict of Interest Qingxue Li and Jeffrey I. Cohen each declare no potential 
      conflicts of interest.
EDAT- 2020/10/24 06:00
MHDA- 2020/10/24 06:01
PMCR- 2020/10/21
CRDT- 2020/10/23 05:58
PHST- 2020/10/23 05:58 [entrez]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2020/10/24 06:01 [medline]
PHST- 2020/10/21 00:00 [pmc-release]
AID - 10.1007/s40588-019-00120-9 [doi]
PST - ppublish
SO  - Curr Clin Microbiol Rep. 2019 Sep;6(3):175-181. doi: 10.1007/s40588-019-00120-9. 
      Epub 2019 Jul 8.