PMID- 33094793
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 11
IP  - 11
DP  - 2020 Nov 18
TI  - 6-Paradol and its glucoside improve memory disorder in mice.
PG  - 9892-9902
LID - 10.1039/d0fo01975e [doi]
AB  - In this study, the effects of 6-paradol (6P) and 6-paradol-beta-glucoside (6PG) on 
      neuritogenesis were investigated using PC12 cells. Treatment with 200 muM 6P or 
      6PG and nerve growth factor (NGF) (5 ng mL-1) increased the number of elongated 
      dendritic cells 8.7 and 5.4 times, respectively, compared to that with NGF (5 ng 
      mL-1) treatment alone. 6P and 6PG did not stimulate the phosphorylation of 
      extracellular regulated protein kinases (ERK)1/2 and cAMP response 
      element-binding protein (CREB) in the tropomyosin receptor kinase A (TrkA) 
      pathway as their activities were suppressed by the pathway inhibitor, k252a. 6P 
      enhanced Ca2+ influx into the cells, whereas 6PG had no effect on Ca2+ influx, 
      although it stimulated PC12 cell differentiation. High-performance liquid 
      chromatography (HPLC) analysis of 6PG in PC12 culture medium suggested that 6PG 
      was deglycosylated to generate 6P, which exhibited the effect. Furthermore, the 
      bioactivities of 6P and 6PG were investigated in mice, and the results revealed 
      that they ameliorated short-term memory loss in animals during behavioral 
      testing.
FAU - Yamaguchi, Kaho
AU  - Yamaguchi K
AD  - Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido 
      501-1193, Gifu, Japan. kosei_y@gifu-u.ac.jp.
FAU - Mitsunaga, Tohru
AU  - Mitsunaga T
FAU - Yamauchi, Kosei
AU  - Yamauchi K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Creb1 protein, mouse)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Glucosides)
RN  - 0 (Ketones)
RN  - 0 (Plant Extracts)
RN  - 6JKA7MAH9C (Guaiacol)
RN  - BO24ID7E9U (6-paradol)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/genetics/metabolism
MH  - Glucosides/*administration & dosage/chemistry
MH  - Guaiacol/administration & dosage/*analogs & derivatives/chemistry
MH  - Humans
MH  - Ketones/*administration & dosage/chemistry
MH  - Male
MH  - Memory/drug effects
MH  - Memory Disorders/*drug therapy/genetics/metabolism/psychology
MH  - Mice
MH  - PC12 Cells
MH  - Phosphorylation
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Receptor, trkA/genetics/metabolism
MH  - Seeds/chemistry
MH  - Signal Transduction/drug effects
MH  - Zingiberaceae/chemistry
EDAT- 2020/10/24 06:00
MHDA- 2021/07/08 06:00
CRDT- 2020/10/23 08:39
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2020/10/23 08:39 [entrez]
AID - 10.1039/d0fo01975e [doi]
PST - ppublish
SO  - Food Funct. 2020 Nov 18;11(11):9892-9902. doi: 10.1039/d0fo01975e.