PMID- 33095678
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 36
IP  - 12
DP  - 2020 Dec
TI  - Estimating minimal clinically important differences for two scales in patients 
      with chronic traumatic brain injury.
PG  - 1999-2007
LID - 10.1080/03007995.2020.1841616 [doi]
AB  - BACKGROUND: This study aimed to establish the minimal clinically important 
      difference (MCID) for the Fugl-Meyer Motor Scale (FMMS) and the Disability Rating 
      Scale (DRS) to evaluate interventions in patients with motor deficits in the 
      chronic phase after traumatic brain injury (TBI). METHODS: MCIDs were established 
      with a structured expert consultation process, the RAND/UCLA modified Delphi 
      method. This process consisted of a literature review and input from a 10-person, 
      multidisciplinary expert panel. The experts were asked to rate meaningfulness of 
      improvements in hypothetical patients and numeric changes via two rounds of 
      ratings and an in-person meeting. RESULTS: The estimated MCIDs were six and five 
      points on the FMMS Upper and Lower Extremity Scale, respectively, and one point 
      on the DRS. The experts argued against establishing an MCID for the combined FMMS 
      because the same change was more likely to be meaningful if concentrated in one 
      extremity and because a meaningful improvement in one extremity implies 
      meaningfulness irrespective of the changes in the other. CONCLUSIONS: This study 
      is the first to establish MCIDs for the FMMS and the DRS in the chronic phase 
      after TBI. The results may be helpful for the design and interpretation of 
      clinical trials of interventions.
FAU - Mattke, Soeren
AU  - Mattke S
AUID- ORCID: 0000-0003-4666-9132
AD  - Department of Economics, University of Southern California, Los Angeles, CA, USA.
FAU - Cramer, Steven C
AU  - Cramer SC
AD  - Department of Neurology, University of California Los Angeles, Los Angeles, CA, 
      USA.
FAU - Wang, Mo
AU  - Wang M
AD  - Department of Economics, University of Southern California, Los Angeles, CA, USA.
FAU - Bettger, Janet Prvu
AU  - Bettger JP
AD  - Health Services Research, Duke University, Durham, NC, USA.
FAU - Cockroft, Kevin M
AU  - Cockroft KM
AD  - Department of Neurosurgery, Penn State University College of Medicine, University 
      Park, PA, USA.
FAU - Feng, Wuwei
AU  - Feng W
AD  - Department of Neurology, Duke University School of Medicine, Durham, NC, USA.
FAU - Jaffee, Michael
AU  - Jaffee M
AD  - Department of Neurology, University of Florida, Gainesville, FL, USA.
FAU - Oyesanya, Tolu O
AU  - Oyesanya TO
AUID- ORCID: 0000-0001-8821-4510
AD  - Health Services Research, Duke University, Durham, NC, USA.
FAU - Puccio, Ava M
AU  - Puccio AM
AD  - Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Temkin, Nancy
AU  - Temkin N
AD  - Department of Neurosurgery, University of Washington, Seattle, WA, USA.
FAU - Winstein, Carolee
AU  - Winstein C
AD  - Department of Economics, University of Southern California, Los Angeles, CA, USA.
FAU - Wolf, Steven L
AU  - Wolf SL
AD  - Department of Physical Therapy, Emory University School of Medicine, Atlanta, GA, 
      USA.
AD  - VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health System, 
      Atlanta, GA, USA.
FAU - Yochelson, Michael R
AU  - Yochelson MR
AD  - Department of Neurology, Shepherd Center, Atlanta, GA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201109
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Brain Injuries, Traumatic/etiology/*therapy
MH  - Disability Evaluation
MH  - Expert Testimony
MH  - Humans
MH  - Lower Extremity/physiopathology
MH  - *Minimal Clinically Important Difference
MH  - Motor Skills
MH  - Upper Extremity/physiopathology
OTO - NOTNLM
OT  - Expert panel
OT  - minimal clinically important difference
OT  - outcomes measurement
OT  - traumatic brain injury
EDAT- 2020/10/24 06:00
MHDA- 2021/06/23 06:00
CRDT- 2020/10/23 17:09
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2020/10/23 17:09 [entrez]
AID - 10.1080/03007995.2020.1841616 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2020 Dec;36(12):1999-2007. doi: 10.1080/03007995.2020.1841616. 
      Epub 2020 Nov 9.