PMID- 33096220
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20220716
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Print)
IS  - 0885-3924 (Linking)
VI  - 61
IP  - 6
DP  - 2021 Jun
TI  - Subjective Toxicity Profiles of Children in Treatment for Cancer: A New Guide to 
      Supportive Care?
PG  - 1188-1195.e2
LID - S0885-3924(20)30823-X [pii]
LID - 10.1016/j.jpainsymman.2020.10.017 [doi]
AB  - CONTEXT: Children and adolescents with cancer experience treatment-related, 
      subjective adverse events (AEs). Identifying distinct groups of patients who 
      predictably experience higher prevalence of AEs could guide patient care. 
      OBJECTIVES: Study aims were to 1) identify groups of children and adolescents 
      reporting AEs using the Pediatric Patient-Reported Outcomes version of the Common 
      Terminology Criteria for Adverse Events (Ped-PRO-CTCAE); 2) determine whether 
      demographic and clinical characteristics predict AE group membership; and 3) 
      examine whether AE group membership was related to the distal outcome of 
      psychological stress. METHODS: Four hundred seventy-seven patients self-reported 
      AEs via the Ped-PRO-CTCAE at T1 (beginning of treatment) and the PROMIS Pediatric 
      Psychological Stress measure at T2 (7-28 days later). Latent class analysis was 
      conducted to identify groups of patients and the relationships of the groups with 
      demographic and clinical characteristics, and with stress. RESULTS: Three 
      distinct a priori unknown AE groups were identified (high AE prevalence, moderate 
      AE prevalence, and low AE prevalence). Females, blacks, patients with high 
      psychological stress, and patients more recently diagnosed were more likely to be 
      in the high AE prevalence group. Gender, age, race, and time since diagnosis were 
      associated with psychological stress. CONCLUSION: Children with cancer are 
      heterogeneous in experiencing subjective AEs. Gender, race, and time since 
      diagnosis were significantly associated with higher subjective AE prevalence that 
      may lead to psychological stress.
CI  - Copyright (c) 2020 American Academy of Hospice and Palliative Medicine. Published 
      by Elsevier Inc. All rights reserved.
FAU - Hinds, Pamela S
AU  - Hinds PS
AD  - Department of Nursing Science, Professional Practice and Quality, Children's 
      National Hospital, Washington, District of Columbia, USA; Department of 
      Pediatrics, The George Washington University, Washington, District of Columbia, 
      USA. Electronic address: pshinds@childrensnational.org.
FAU - Weaver, Meaghann S
AU  - Weaver MS
AD  - Division of Pediatric Palliative Care, Children's Hospital and Medical Center, 
      Omaha, Nebraska, USA; Division of Pediatric Oncology, Children's Hospital and 
      Medical Center, Omaha, Nebraska, USA.
FAU - Withycombe, Janice S
AU  - Withycombe JS
AD  - School of Nursing, Clemson University, Clemson, South Carolina, USA.
FAU - Baker, Justin N
AU  - Baker JN
AD  - St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
FAU - Jacobs, Shana S
AU  - Jacobs SS
AD  - Department of Pediatrics, Children's National Hospital, The George Washington 
      University, Washington, District of Columbia, USA.
FAU - Mack, Jennifer W
AU  - Mack JW
AD  - Department of Pediatric Oncology and Center for Population Sciences, Dana-Farber 
      Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.
FAU - Maurer, Scott H
AU  - Maurer SH
AD  - Department of Pediatrics, University of Pittsburgh School of Medicine, 
      Pittsburgh, Pennsylvania, USA; Division of Palliative Medicine and Supportive 
      Care, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
FAU - McFatrich, Molly
AU  - McFatrich M
AD  - Population Health Sciences, Duke University School of Medicine, Durham, North 
      Carolina, USA.
FAU - Pinheiro, Laura C
AU  - Pinheiro LC
AD  - Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
FAU - Reeve, Bryce B
AU  - Reeve BB
AD  - Department of Population Health Sciences, Duke Cancer Institute, Duke University 
      School of Medicine, Durham, North Carolina, USA; Department of Pediatrics, Duke 
      Cancer Institute, Duke University School of Medicine, Durham, North Carolina, 
      USA.
FAU - Wang, Jichuan
AU  - Wang J
AD  - Division of Biostatistics and Study Methodology, Children's National Hospital, 
      Washington, District of Columbia, USA; Epidemiology and Biostatistics, The George 
      Washington University School of Medicine and Health Sciences, Washington, 
      District of Columbia, USA.
LA  - eng
GR  - R01 CA175759/CA/NCI NIH HHS/United States
GR  - U19 AR069522/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201020
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - *Neoplasms/epidemiology/therapy
MH  - Patient Reported Outcome Measures
MH  - Research
MH  - Self Report
PMC - PMC8055722
MID - NIHMS1650425
OTO - NOTNLM
OT  - PRO-CTCAE
OT  - PROMIS
OT  - Pediatric oncology
OT  - latent class analysis
OT  - symptom cluster
EDAT- 2020/10/24 06:00
MHDA- 2021/07/10 06:00
PMCR- 2022/06/01
CRDT- 2020/10/23 20:11
PHST- 2020/07/09 00:00 [received]
PHST- 2020/10/08 00:00 [revised]
PHST- 2020/10/10 00:00 [accepted]
PHST- 2020/10/24 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/10/23 20:11 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - S0885-3924(20)30823-X [pii]
AID - 10.1016/j.jpainsymman.2020.10.017 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2021 Jun;61(6):1188-1195.e2. doi: 
      10.1016/j.jpainsymman.2020.10.017. Epub 2020 Oct 20.