PMID- 33097232
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 273
DP  - 2021 Jun
TI  - Serum perfluoroalkyl substances in relation to lipid metabolism in Chinese 
      pregnant women.
PG  - 128566
LID - S0045-6535(20)32761-2 [pii]
LID - 10.1016/j.chemosphere.2020.128566 [doi]
AB  - Laboratory and epidemiologic studies suggested that exposure to perfluoroalkyl 
      substances (PFASs) could affect lipid metabolisms, but data remain limited for 
      pregnant women. A total of 436 pregnant women were selected in Tangshan City, 
      North China. Serum levels of 11 PFASs were determined in the early term of 
      pregnancy. Four lipids (total cholesterol (TC), triglyceride (TG), high-density 
      lipoprotein (HDL), and low-density lipoprotein (LDL)) were measured in the late 
      term of pregnancy. Of 11 PFASs, seven had a detection rate of greater than 70%. 
      After adjusting for potential confounders, natural log-transformed 
      perfluororohexanesulfonic acid (ln PFHxS) was positively associated with TC (beta: 
      0.184, 95% CI: 0.045-0.321), HDL (beta: 0.040, 95% CI: 0.001-0.083), and LDL (beta: 
      0.091, 95% CI: 0.001-0.185). Ln perfluoroundecanoic acid (PFUdA) was positively 
      associated with HDL (beta: 0.021, 95% CI: 0.001-0.044), while Ln perfluorodecanoic 
      acid (PFDA) was negatively associated with LDL (beta: -0.053, 95% CI: -0.098 approximately -0.009) 
      and ln perfluorootanoic acid (PFOA) was negatively associated with LDL/HDL 
      (beta: -0.042, 95% CI: -0.075 approximately -0.009). In principal component analysis, the 
      component with a large loading of 31.3% for PFOA, perfluorononanoic acid (PFNA), 
      PFDA and PFUdA showed a negative association with LDL/HDL. After serum 
      concentrations of PFASs were categorized into quartiles, a higher level of TC was 
      seen in the second quartile of PFOA or PFNA than the first quartile, but a lower 
      LDL/HDL ratio was seen in the fourth quartile of PFOA, PFUdA or PFDA. These 
      results suggested that exposure to PFASs has a potential to influence lipid 
      metabolisms in pregnant women.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Yang, Jiaqi
AU  - Yang J
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China.
FAU - Wang, Hexing
AU  - Wang H
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China.
FAU - Du, Hongyi
AU  - Du H
AD  - Institute of Reproductive and Child Health, School of Public Health, Peking 
      University Health Science Center, Beijing, 100083, China.
FAU - Fang, Hongji
AU  - Fang H
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China.
FAU - Han, Minghui
AU  - Han M
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China.
FAU - Xu, Linji
AU  - Xu L
AD  - Maternal and Child Health Care Hospital, Tangshan Municipality, No. 14 South 
      Jianshe Road, Tangshan, 063000, Hebei province, China.
FAU - Liu, Shuping
AU  - Liu S
AD  - Maternal and Child Health Care Hospital, Tangshan Municipality, No. 14 South 
      Jianshe Road, Tangshan, 063000, Hebei province, China.
FAU - Yi, Jianping
AU  - Yi J
AD  - Maternal and Child Health Care Hospital, Tangshan Municipality, No. 14 South 
      Jianshe Road, Tangshan, 063000, Hebei province, China.
FAU - Chen, Yue
AU  - Chen Y
AD  - School of Epidemiology and Public Health, Faculty of Medicine, University of 
      Ottawa, Ottawa, Ontario, K1G 5Z3, Canada.
FAU - Jiang, Qingwu
AU  - Jiang Q
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China.
FAU - He, Gengsheng
AU  - He G
AD  - School of Public Health, Key Laboratory of Public Health Safety of Ministry of 
      Education, Fudan University, Shanghai, 200032, China. Electronic address: 
      gshe@shmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - China
MH  - Cities
MH  - *Environmental Pollutants
MH  - Female
MH  - *Fluorocarbons
MH  - Humans
MH  - Lipid Metabolism
MH  - Pregnancy
MH  - Pregnant Women
OTO - NOTNLM
OT  - Lipid metabolism
OT  - North China
OT  - Polyfluoroalkyl substances
OT  - Pregnant women
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/10/25 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/10/24 05:26
PHST- 2020/08/09 00:00 [received]
PHST- 2020/10/03 00:00 [revised]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/10/25 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/10/24 05:26 [entrez]
AID - S0045-6535(20)32761-2 [pii]
AID - 10.1016/j.chemosphere.2020.128566 [doi]
PST - ppublish
SO  - Chemosphere. 2021 Jun;273:128566. doi: 10.1016/j.chemosphere.2020.128566. Epub 
      2020 Oct 8.