PMID- 33098371
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1744-9987 (Electronic)
IS  - 1744-9979 (Linking)
VI  - 25
IP  - 5
DP  - 2021 Oct
TI  - Effect of type 2 diabetes mellitus on efficacy and safety of therapeutic 
      apheresis for severe hypertriglyceridemia.
PG  - 681-686
LID - 10.1111/1744-9987.13603 [doi]
AB  - The efficacy and safety of triglyceride (TG) apheresis in patients with type 2 
      diabetes mellitus (DM) is unclear. Diabetic complications may predispose patients 
      to adverse events (AEs) associated with the apheresis procedure, and diabetic 
      dyslipidemia may negatively affect the efficacy of therapeutic apheresis (TA). We 
      investigated the effect of DM on the efficacy and complications of TA. Patients 
      with severe hypertriglyceridemia who underwent apheresis for treatment or for the 
      prevention of acute pancreatitis were included in this retrospective study. 
      Epidemiological data, lipid parameters, and AEs were recorded before and after 
      each therapeutic session. A total of 166 procedures were performed in 27 
      patients. Group 1 included 17 patients with type 2 DM, and Group 2 included 10 
      patients without DM. The mean percentage decrease in TG levels (TG%) was higher 
      in Group 1 (71.9% vs 60.6%, P < .001). The TG% was negatively correlated with the 
      duration of DM in Group 1 (r = -.49, P < .001). The total number of TA sessions 
      was 142 in patients who underwent double filtration plasmapheresis and 24 in 
      patients who underwent therapeutic plasma exchange. We observed 9 (5.4%) 
      mild-to-moderate AEs. No intergroup difference was observed in the total number 
      of AEs (P = .06). TA is safe and effective in patients with type 2 DM with severe 
      hypertriglyceridemia.
CI  - (c) 2020 International Society for Apheresis, Japanese Society for Apheresis, and 
      Japanese Society for Dialysis Therapy.
FAU - Bagir, Gulay Simsek
AU  - Bagir GS
AUID- ORCID: 0000-0001-5747-407X
AD  - Department of Endocrinology and Metabolism, Baskent University Faculty of 
      Medicine, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana, 
      Turkey.
FAU - Bakiner, Okan Sefa
AU  - Bakiner OS
AD  - Department of Endocrinology and Metabolism, Baskent University Faculty of 
      Medicine, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana, 
      Turkey.
FAU - Haydardedeoglu, Filiz Eksi
AU  - Haydardedeoglu FE
AD  - Department of Endocrinology and Metabolism, Baskent University Faculty of 
      Medicine, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana, 
      Turkey.
FAU - Araz, Filiz
AU  - Araz F
AD  - Department of Gastroenterology, Baskent University Faculty of Medicine, Adana Dr. 
      Turgut Noyan Teaching and Medical Research Center, Adana, Turkey.
FAU - Ertorer, Melek Eda
AU  - Ertorer ME
AD  - Department of Endocrinology and Metabolism, Baskent University Faculty of 
      Medicine, Adana Dr. Turgut Noyan Teaching and Medical Research Center, Adana, 
      Turkey.
FAU - Kozanoglu, Ilknur
AU  - Kozanoglu I
AD  - Department of Physiology, Baskent University Faculty of Medicine, Adana Dr. 
      Turgut Noyan Teaching and Medical Research Center, Apheresis Unit, Adana, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20201213
PL  - Australia
TA  - Ther Apher Dial
JT  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the 
      International Society for Apheresis, the Japanese Society for Apheresis, the 
      Japanese Society for Dialysis Therapy
JID - 101181252
SB  - IM
MH  - Adult
MH  - Blood Component Removal/adverse effects/*methods
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Hypertriglyceridemia/*complications/*therapy
MH  - Male
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - apheresis
OT  - complications
OT  - diabetes mellitus
OT  - hypertriglyceridemia
OT  - safety
EDAT- 2020/10/25 06:00
MHDA- 2022/01/18 06:00
CRDT- 2020/10/24 08:34
PHST- 2020/09/16 00:00 [revised]
PHST- 2020/05/27 00:00 [received]
PHST- 2020/10/21 00:00 [accepted]
PHST- 2020/10/25 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2020/10/24 08:34 [entrez]
AID - 10.1111/1744-9987.13603 [doi]
PST - ppublish
SO  - Ther Apher Dial. 2021 Oct;25(5):681-686. doi: 10.1111/1744-9987.13603. Epub 2020 
      Dec 13.