PMID- 33098618
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1552-4930 (Electronic)
IS  - 1552-4922 (Linking)
VI  - 99
IP  - 3
DP  - 2021 Mar
TI  - Comprehensive Phenotyping of Dendritic Cells in Cancer Patients by Flow 
      Cytometry.
PG  - 218-230
LID - 10.1002/cyto.a.24245 [doi]
AB  - Dendritic cells (DCs) play a crucial role in the complex interplay between tumor 
      cells and the immune system. During the elimination phase of cancer 
      immunoediting, immunostimulatory DCs are critical for the control of tumor 
      growth. During the escape phase, regulatory DCs sustain tumor tolerance and 
      contribute to the development of the immunosuppressive tumor microenvironment 
      that characterizes this phase. Moreover, increasing evidence indicates that DCs 
      are also critical for the success of cancer immunotherapy. Hence, there is 
      increasing need to fully characterize DC subsets and their activatory/inhibitory 
      profile in cancer patients. In this review, we describe the role played by 
      different DC subsets in the different phases of cancer immunoediting, the 
      function exerted by different activatory and inhibitory molecules expressed on DC 
      surface, and the cytokines produced by distinct DC subsets, in order to provide 
      an overview on the DC features that may be useful to be assessed when dealing 
      with the flow cytometric characterization of DCs in cancer patients. (c) 2020 
      International Society for Advancement of Cytometry.
CI  - (c) 2020 International Society for Advancement of Cytometry.
FAU - Carenza, Claudia
AU  - Carenza C
AD  - Department of Medical Biotechnologies and Translational Medicine, University of 
      Milan, Milan, Italy.
AD  - Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research 
      Center-IRCCS, Rozzano, Milan, Italy.
FAU - Franzese, Sara
AU  - Franzese S
AD  - Department of Medical Biotechnologies and Translational Medicine, University of 
      Milan, Milan, Italy.
AD  - Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research 
      Center-IRCCS, Rozzano, Milan, Italy.
FAU - Calcaterra, Francesca
AU  - Calcaterra F
AD  - Department of Medical Biotechnologies and Translational Medicine, University of 
      Milan, Milan, Italy.
AD  - Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research 
      Center-IRCCS, Rozzano, Milan, Italy.
FAU - Mavilio, Domenico
AU  - Mavilio D
AD  - Department of Medical Biotechnologies and Translational Medicine, University of 
      Milan, Milan, Italy.
AD  - Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research 
      Center-IRCCS, Rozzano, Milan, Italy.
FAU - Della Bella, Silvia
AU  - Della Bella S
AUID- ORCID: 0000-0003-0818-5049
AD  - Department of Medical Biotechnologies and Translational Medicine, University of 
      Milan, Milan, Italy.
AD  - Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research 
      Center-IRCCS, Rozzano, Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201111
PL  - United States
TA  - Cytometry A
JT  - Cytometry. Part A : the journal of the International Society for Analytical 
      Cytology
JID - 101235694
SB  - IM
MH  - *Dendritic Cells
MH  - Flow Cytometry
MH  - Humans
MH  - Immune Tolerance
MH  - Immunotherapy
MH  - *Neoplasms
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - cancer immunoediting
OT  - conventional DCs (cDCs)
OT  - costimulatory molecules
OT  - flow cytometry
OT  - human DCs
OT  - immune checkpoints
OT  - peripheral blood DCs (PBDCs)
OT  - plasmacytoid DCs (pDCs)
OT  - tumor-associated DCs (TADCs)
EDAT- 2020/10/25 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/10/24 12:08
PHST- 2020/08/27 00:00 [received]
PHST- 2020/10/08 00:00 [revised]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/10/25 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/10/24 12:08 [entrez]
AID - 10.1002/cyto.a.24245 [doi]
PST - ppublish
SO  - Cytometry A. 2021 Mar;99(3):218-230. doi: 10.1002/cyto.a.24245. Epub 2020 Nov 11.