PMID- 33098663
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 76
IP  - 2
DP  - 2021 Feb
TI  - Roles of follicular helper and regulatory T cells in allergic diseases and 
      allergen immunotherapy.
PG  - 456-470
LID - 10.1111/all.14639 [doi]
AB  - Allergic diseases are characterized by overactive type 2 immune responses to 
      allergens and immunoglobulin E (IgE)-mediated hypersensitivity. Emerging evidence 
      suggests that follicular helper T (T(FH) ) cells, rather than type 2 T-helper 
      (T(H) 2) cells, play a crucial role in controlling IgE production. However, 
      follicular regulatory T (T(FR) ) cells, a specialized subset of regulatory T 
      (T(REG) ) cells resident in B-cell follicles, restricts T(FH) cell-mediated help 
      in extrafollicular antibody production, germinal center (GC) formation, 
      immunoglobulin affinity maturation, and long-lived, high-affinity plasma and 
      memory B-cell differentiation. In mouse models of allergic asthma and food 
      allergy, CXCR5(+) T(FH) cells, not CXCR5(-) conventional T(H) 2 cells, are needed 
      to support IgE production, otherwise exacerbated by CXCR5(+) T(FR) cell deletion. 
      Upregulation of T(FH) cell activities, including a skewing toward type 2 T(FH) 
      (T(FH) 2) and IL-13 producing T(FH) (T(FH) 13) phenotypes, and defects in T(FR) 
      cells have been identified in patients with allergic diseases. Allergen 
      immunotherapy (AIT) reinstates the balance between T(FH) and T(FR) cells in 
      patients with allergic diseases, resulting in clinical benefits. Collectively, 
      further understanding of T(FH) and T(FR) cells and their role in the 
      immunopathogenesis of allergic diseases creates opportunities to develop novel 
      therapeutic approaches.
CI  - (c) 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons 
      Ltd.
FAU - Yao, Yin
AU  - Yao Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
AD  - The University of Queensland Diamantina Institute, Faculty of Medicine, The 
      University of Queensland, Brisbane, Qld, Australia.
FAU - Chen, Cai-Ling
AU  - Chen CL
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
FAU - Yu, Di
AU  - Yu D
AD  - The University of Queensland Diamantina Institute, Faculty of Medicine, The 
      University of Queensland, Brisbane, Qld, Australia.
FAU - Liu, Zheng
AU  - Liu Z
AUID- ORCID: 0000-0002-4168-6702
AD  - Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201104
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Animals
MH  - B-Lymphocytes
MH  - Desensitization, Immunologic
MH  - Germinal Center
MH  - Humans
MH  - *Hypersensitivity/therapy
MH  - Mice
MH  - T-Lymphocytes, Helper-Inducer
MH  - *T-Lymphocytes, Regulatory
OTO - NOTNLM
OT  - allergen immunotherapy
OT  - allergy
OT  - follicular helper T cell
OT  - follicular regulatory T cell
OT  - immunoglobulin E
EDAT- 2020/10/25 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/10/24 17:05
PHST- 2020/07/09 00:00 [received]
PHST- 2020/10/06 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/10/25 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/10/24 17:05 [entrez]
AID - 10.1111/all.14639 [doi]
PST - ppublish
SO  - Allergy. 2021 Feb;76(2):456-470. doi: 10.1111/all.14639. Epub 2020 Nov 4.