PMID- 33098953
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20220531
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 326
DP  - 2021 Mar 1
TI  - The aortic root in repaired tetralogy of Fallot: Serial measurements and impact 
      of losartan treatment.
PG  - 88-91
LID - S0167-5273(20)33990-5 [pii]
LID - 10.1016/j.ijcard.2020.10.037 [doi]
AB  - BACKGROUND: Aortic root dilatation is common in adults with repaired tetralogy of 
      Fallot (rTOF) and might lead to aortic dissection. However, little is known on 
      progression of aortic dilatation and the effect of pharmaceutical treatment. This 
      study aims to determine factors associated with aortic growth and investigate 
      effects of losartan. METHODS AND RESULTS: We performed a prespecified analysis 
      from the 1:1 randomized, double-blind REDEFINE trial. Aortic root diameters were 
      measured at baseline and after 2.0 +/- 0.3 years of follow-up using cardiovascular 
      magnetic resonance (CMR) imaging. A total of 66 patients were included (68% men, 
      age 40 +/- 12 years, baseline aortic root 37 +/- 6 mm, 32% aortic dilatation 
      (>40 mm)). There was a trend towards slow aortic root growth (+0.6 +/- 2.3 mm after 
      two years, p = 0.06) (n = 60). LV stroke volume was the only factor associated 
      with both a larger baseline aortic root (beta: 0.09 mm/ml (95% C.I.:0.02, 0.15), 
      p = 0.010) and with aortic growth during follow-up (beta: 0.04 mm/ml (95% 
      C.I.:0.005, 0.066), p = 0.024), after correction for age, sex, and body surface 
      area using linear regression analysis. No treatment effect of losartan was found 
      (p = 0.17). CONCLUSIONS: Aortic root dilatation was present in about one-third of 
      rTOF patients. A larger LV stroke volume was associated with both a larger 
      baseline aortic root and ongoing growth. Our findings provide no arguments for 
      lower aortic diameter thresholds for prophylactic surgery compared to the general 
      population.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Woudstra, O I
AU  - Woudstra OI
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands; Department of Cardiology, University Medical Center Utrecht, 
      Utrecht, the Netherlands.
FAU - Ghanam, A
AU  - Ghanam A
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands.
FAU - Vliegen, H W
AU  - Vliegen HW
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - van Dijk, A P J
AU  - van Dijk APJ
AD  - Department of Cardiology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - van Melle, J P
AU  - van Melle JP
AD  - Department of Cardiology, Groningen University Medical Center, Groningen, the 
      Netherlands.
FAU - Groenink, M
AU  - Groenink M
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands.
FAU - Meijboom, F J
AU  - Meijboom FJ
AD  - Department of Cardiology, University Medical Center Utrecht, Utrecht, the 
      Netherlands.
FAU - Post, M C
AU  - Post MC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Mulder, B J M
AU  - Mulder BJM
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands.
FAU - Bouma, B J
AU  - Bouma BJ
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands.
FAU - Bokma, J P
AU  - Bokma JP
AD  - Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam UMC, 
      University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the 
      Netherlands. Electronic address: j.p.bokma@amsterdamumc.nl.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20201021
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Adult
MH  - Aorta/diagnostic imaging
MH  - *Aortic Diseases
MH  - Dilatation, Pathologic
MH  - Female
MH  - Humans
MH  - Losartan
MH  - Male
MH  - Middle Aged
MH  - *Tetralogy of Fallot/diagnostic imaging/surgery
OTO - NOTNLM
OT  - Aortic root
OT  - Cardiovascular magnetic resonance imaging
OT  - Tetralogy of Fallot
COIS- Declaration of Competing Interest None.
EDAT- 2020/10/26 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/10/25 00:01
PHST- 2020/06/16 00:00 [received]
PHST- 2020/09/01 00:00 [revised]
PHST- 2020/10/07 00:00 [accepted]
PHST- 2020/10/26 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/10/25 00:01 [entrez]
AID - S0167-5273(20)33990-5 [pii]
AID - 10.1016/j.ijcard.2020.10.037 [doi]
PST - ppublish
SO  - Int J Cardiol. 2021 Mar 1;326:88-91. doi: 10.1016/j.ijcard.2020.10.037. Epub 2020 
      Oct 21.