PMID- 33099138
OWN - NLM
STAT- MEDLINE
DCOM- 20210108
LR  - 20210108
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 208
DP  - 2021 Jan 15
TI  - Association between prenatal exposure to persistent organic pollutants and 
      neurodevelopment in early life: A mother-child cohort (Shanghai, China).
PG  - 111479
LID - S0147-6513(20)31316-6 [pii]
LID - 10.1016/j.ecoenv.2020.111479 [doi]
AB  - As common environmental pollutants, persistent organic pollutants (POPs) that are 
      widely applied in industry and agriculture have adverse effects on 
      neurodevelopment. However, evidence on the neurotoxicity of POPs in neural 
      development of offspring is limited. This study explored the relationship between 
      prenatal exposure to POPs and neurodevelopment of 18-month-old toddlers in a 
      mother-child cohort in Shanghai, China. In this study, we determined exposure 
      levels of 37 POPs in cord blood serum collected at the time of delivery. The 
      detection rate of pollutants HCB, beta-HCH, and p,p'-DDE was higher than 60%, so 
      these will be discussed in the following analysis. From birth to approximately 18 
      months, we followed up infants to longitudinally explore whether POPs influenced 
      their language, motor, and cognitive development according to a Bayley-Ⅲ 
      assessment . Based on multivariable regression analyses, the beta-HCH concentration 
      in cord serum was negatively related to motor development scores in children at 
      18 months by adjusting for the covariates, but there was no change in language 
      and cognition. Further piecewise linear regression analysis showed that a cord 
      serum beta-HCH concentration greater than 0.2 mug/L had a significantly negative 
      correlation with the motor development scores. p,p'-DDE was positively associated 
      with language development at 18 months before and after adjusting for covariates. 
      But prenatal HCB levels were not associated with any of the Bayley-Ⅲ subscales at 
      18 months. We concluded that prenatal exposure to beta-HCH might have adverse 
      effects on infants' motor development. The minimum harmful concentration of beta-HCH 
      was estimated at 0.2 mug/L in cord serum. The unexpected positive association 
      between p,p'-DDT and language development could be due to live birth bias.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Wang, Susu
AU  - Wang S
AD  - School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
FAU - Hu, Chunping
AU  - Hu C
AD  - School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
FAU - Lu, Anxin
AU  - Lu A
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Wang, Yaqian
AU  - Wang Y
AD  - School of Public Health, Shanghai Jiao Tong University, Shanghai, China.
FAU - Cao, Lulu
AU  - Cao L
AD  - Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Wu, Wei
AU  - Wu W
AD  - Qilu Children's Hospital of Shandong University, Shandong, Jinan, China.
FAU - Li, Hui
AU  - Li H
AD  - Jining No.1 People's Hospital, Shandong, Jining, China.
FAU - Wu, Meiqin
AU  - Wu M
AD  - The Women and Children's Health Care Department Shanghai First Maternity and 
      Infant Hospital, Tongji University School of Medicine, No.2699, West Gaoke Road, 
      Shanghai 200040, China. Electronic address: wmqmaomao@sjtu.edu.cn.
FAU - Yan, Chonghuai
AU  - Yan C
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20201021
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - CIW5S16655 (DDT)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Child Development/*drug effects
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Cohort Studies
MH  - DDT
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Environmental Pollutants/toxicity
MH  - Female
MH  - Fetal Blood
MH  - Hexachlorocyclohexane
MH  - Humans
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - Infant
MH  - Male
MH  - Maternal Exposure/adverse effects/*statistics & numerical data
MH  - Mothers
MH  - Persistent Organic Pollutants/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/*epidemiology
OTO - NOTNLM
OT  - Bayley-Ⅲ
OT  - Infants
OT  - Neurodevelopment
OT  - Persistent organic pollutants
EDAT- 2020/10/26 06:00
MHDA- 2021/01/09 06:00
CRDT- 2020/10/25 00:05
PHST- 2020/05/26 00:00 [received]
PHST- 2020/10/06 00:00 [revised]
PHST- 2020/10/09 00:00 [accepted]
PHST- 2020/10/26 06:00 [pubmed]
PHST- 2021/01/09 06:00 [medline]
PHST- 2020/10/25 00:05 [entrez]
AID - S0147-6513(20)31316-6 [pii]
AID - 10.1016/j.ecoenv.2020.111479 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Jan 15;208:111479. doi: 
      10.1016/j.ecoenv.2020.111479. Epub 2020 Oct 21.