PMID- 33101083
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 11
DP  - 2020
TI  - Association Between Behavioral Dysexecutive Syndrome and the Health-Related 
      Quality of Life Among Stroke Survivors.
PG  - 563930
LID - 10.3389/fpsyt.2020.563930 [doi]
LID - 563930
AB  - AIM: Behavioral dysexecutive syndrome (BDES) is one common neuropsychiatric 
      comorbidity after stroke. Despite evidences suggesting the adverse effect of BDES 
      on the survivors' outcome, little is known about the association between BDES and 
      the health-related quality of life (HRQoL) among stroke survivors and how BDES 
      impacts the HRQoL. This study aimed to address these questions. METHODS: This 
      study included 219 patients with acute ischemic stroke consecutively admitted to 
      a regional hospital in Hong Kong. BDES was defined as a Chinese version of the 
      Dysexecutive Questionnaire (DEX) score of >/=20 assessed at three months after 
      stroke. The HRQoL was assessed with the Chinese version of the Stroke-Specific 
      Quality of Life (SSQoL) questionnaire encompassing 12 domains. Multivariate 
      linear regression models were employed to examine the association between BDES 
      symptoms and the SSQoL total and domain scores. Structural equation model (SEM) 
      was further constructed to delineate the linking pathways linking BDES and the 
      HRQoL. RESULTS: The study sample compromised mainly older patients with mild to 
      moderate ischemic stroke. Compared with patients without BDES, those with BDES 
      exhibited poorer performances regarding with the summarized SSQoL (226.2 +/- 18.8 
      vs. 200.3 +/- 29.8, p < 0.001) and almost all domains. The BDES symptoms were 
      independently contributed to the whole HRQoL (SSQoL total score) (beta = -0.20, p = 
      0.002), specifically to the domains in personality (beta = -0.34, p < 0.001), 
      language (beta = -0.22, p = 0.01), and work/productivity (beta = -0.32, p < 0.001), 
      after adjusting demographic and clinical characteristics in linear models. The 
      impacts of the BDES symptoms on the HRQoL were mainly explained by the indirect 
      path mediated by depression and anxiety (path coefficient = -0.27, p < 0.05) 
      rather than physical disability, while the resting was elucidated by the path 
      directly linking BDES to the HRQoL (path coefficient = -0.17, p < 0.05). 
      CONCLUSION: The present study preliminarily demonstrated a potential association 
      between BDES and a lower level of the HRQoL, predominantly in domains of 
      personality, language, and work/productivityafter acute ischemic stroke. This 
      study also offered insights into the underlying mechanisms linking BDES and the 
      HRQoL, implicating that integrative psychological therapies were urged to achieve 
      better HRQoL after stroke.
CI  - Copyright (c) 2020 Liang, Wang, Yang, Chen, Mok, Ungvari, Chu, Kim and Tang.
FAU - Liang, Yannis Yan
AU  - Liang YY
AD  - Stroke Center and Department of Neurology, The First Affiliated Hospital, Jinan 
      University, Guangzhou, China.
FAU - Wang, Lisha
AU  - Wang L
AD  - Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, Hong 
      Kong.
FAU - Yang, Ying
AU  - Yang Y
AD  - Stroke Center and Department of Neurology, The First Affiliated Hospital, Jinan 
      University, Guangzhou, China.
FAU - Chen, Yangkun
AU  - Chen Y
AD  - Department of Neurology, Dongguan People's Hospital, Dongguan, China.
FAU - Mok, Vincent C T
AU  - Mok VCT
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong, Hong Kong.
FAU - Ungvari, Gabor S
AU  - Ungvari GS
AD  - University of Notre Dame Australia/Graylands Hospital, Perth, WA, Australia.
FAU - Chu, Winnie C W
AU  - Chu WCW
AD  - Department of Imaging and Interventional Radiology, The Chinese University of 
      Hong Kong, Hong Kong, Hong Kong.
FAU - Kim, Jong S
AU  - Kim JS
AD  - Department of Neurology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, South Korea.
FAU - Tang, Wai-Kwong
AU  - Tang WK
AD  - Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, Hong 
      Kong.
AD  - Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, Hong 
      Kong.
LA  - eng
PT  - Journal Article
DEP - 20200908
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC7506061
OTO - NOTNLM
OT  - depression
OT  - dysexecutive syndrome
OT  - health-related quality of life
OT  - stroke
OT  - structural equation model
EDAT- 2020/10/27 06:00
MHDA- 2020/10/27 06:01
PMCR- 2020/09/08
CRDT- 2020/10/26 05:21
PHST- 2020/05/21 00:00 [received]
PHST- 2020/08/14 00:00 [accepted]
PHST- 2020/10/26 05:21 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2020/10/27 06:01 [medline]
PHST- 2020/09/08 00:00 [pmc-release]
AID - 10.3389/fpsyt.2020.563930 [doi]
PST - epublish
SO  - Front Psychiatry. 2020 Sep 8;11:563930. doi: 10.3389/fpsyt.2020.563930. 
      eCollection 2020.