PMID- 33101173
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201028
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Changes in Brain Function Networks in Patients With Amnestic Mild Cognitive 
      Impairment: A Resting-State fMRI Study.
PG  - 554032
LID - 10.3389/fneur.2020.554032 [doi]
LID - 554032
AB  - Patients with amnestic mild cognitive impairment (aMCI) are at high risk of 
      developing dementia. This study used resting-state functional magnetic resonance 
      imaging (rs-fMRI) and an independent component analysis (ICA) approach to explore 
      changes in functional connectivity (FC) in the default mode network (DMN), 
      executive control network (ECN), and salience network (SN). Thirty patients with 
      aMCI and 30 healthy controls (HCs) were enrolled. All the participants underwent 
      an rs-fMRI scan. The brain FC in DMN, ECN, and SN was calculated using the ICA 
      approach. We found that the FC of brain regions in DMN decreased significantly 
      and that of brain regions in ECN increased, which was in accordance with the 
      findings of previous studies on Alzheimer's disease (AD) and aMCI. We also found 
      that the FC of brain regions in SN increased, which was different from the 
      findings of previous studies on AD. The increase in FC in brain regions in SN 
      might result from different pathophysiological states in AD and aMCI, indicating 
      that a decrease in FC in SN does not occur in a person with aMCI. These results 
      are consistent with those of previous studies using the voxel-mirrored homotopic 
      connectivity approach and seed-based correlation analysis. We therefore 
      considered that the decrease in FC in DMN and the increase in FC in ECN and SN 
      might be peculiar patterns observed on the rs-fMRI of a person with aMCI. These 
      findings may contribute to the development of imaging biomarkers for the 
      diagnosis of aMCI.
CI  - Copyright (c) 2020 Li, Wang, Liu, Cao, Cai, Jiang, Yang, Yang and Asakawa.
FAU - Li, Xiaoling
AU  - Li X
AD  - First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Wang, Feng
AU  - Wang F
AD  - First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Liu, Xiaohui
AU  - Liu X
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Cao, Danna
AU  - Cao D
AD  - First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Cai, Lina
AU  - Cai L
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Jiang, Xiaoxu
AU  - Jiang X
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Yang, Xu
AU  - Yang X
AD  - Division of CT and MRI, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Yang, Tiansong
AU  - Yang T
AD  - First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 
      China.
FAU - Asakawa, Tetsuya
AU  - Asakawa T
AD  - Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, 
      Japan.
AD  - Research Base of Traditional Chinese Medicine Syndrome, Fujian University of 
      Traditional Chinese Medicine, Fuzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200930
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7554345
OTO - NOTNLM
OT  - amnestic mild cognitive impairment
OT  - default mode network
OT  - executive control network
OT  - functional connectivity
OT  - resting-state functional magnetic resonance imaging
OT  - salience network
EDAT- 2020/10/27 06:00
MHDA- 2020/10/27 06:01
PMCR- 2020/09/30
CRDT- 2020/10/26 05:21
PHST- 2020/04/21 00:00 [received]
PHST- 2020/09/02 00:00 [accepted]
PHST- 2020/10/26 05:21 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2020/10/27 06:01 [medline]
PHST- 2020/09/30 00:00 [pmc-release]
AID - 10.3389/fneur.2020.554032 [doi]
PST - epublish
SO  - Front Neurol. 2020 Sep 30;11:554032. doi: 10.3389/fneur.2020.554032. eCollection 
      2020.