PMID- 33101181
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201028
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Unfractionated Heparin in SARS-CoV-2 Pneumonia: Ischemic Stroke Case Report.
PG  - 573356
LID - 10.3389/fneur.2020.573356 [doi]
LID - 573356
AB  - Thromboembolism is a known phenomenon in patients with Coronavirus disease 2019 
      (COVID-19). Recent investigations have revealed that a significant proportion of 
      those hospitalized with severe COVID-19 demonstrate clinical and laboratory 
      markers compatible with hypercoagulability, which is differentiated from 
      disseminated intravascular coagulation (DIC), termed COVID-associated 
      coagulopathy. Additionally, there is increasing concern for development of acute 
      ischemic stroke because of this hypercoagulable state. We present a patient with 
      COVID-19 pneumonia who was managed with unfractionated heparin (UFH) infusion and 
      developed a large ischemic infarct shortly after cessation of the infusion. In 
      retrospect, the patient's coagulation parameters were consistent with overt DIC, 
      although some of these parameters are easily masked by the effects of UFH. These 
      findings emphasize the importance of anticoagulation as well as its careful 
      discontinuation, as failure to do so may result in a significant thromboembolic 
      event.
CI  - Copyright (c) 2020 Efendizade, Dmytriw, Hewitt and Davies.
FAU - Efendizade, Aslan
AU  - Efendizade A
AD  - Department of Diagnostic Radiology, State University of New York (SUNY) Downstate 
      Medical Center, University Hospital Brooklyn, Brooklyn, NY, United States.
FAU - Dmytriw, Adam A
AU  - Dmytriw AA
AD  - Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
AD  - Department of Neuroradiology & Neurointervention, Brigham and Women's Hospital, 
      Boston, MA, United States.
FAU - Hewitt, Kevin
AU  - Hewitt K
AD  - Department of Diagnostic Radiology, State University of New York (SUNY) Downstate 
      Medical Center, University Hospital Brooklyn, Brooklyn, NY, United States.
FAU - Davies, Gwynivere A
AU  - Davies GA
AD  - Department of Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, 
      ON, Canada.
LA  - eng
PT  - Case Reports
DEP - 20200925
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7545009
OTO - NOTNLM
OT  - COVID-19
OT  - anticoagulation
OT  - heparin
OT  - stroke
OT  - thromboembolism
EDAT- 2020/10/27 06:00
MHDA- 2020/10/27 06:01
PMCR- 2020/09/25
CRDT- 2020/10/26 05:21
PHST- 2020/06/16 00:00 [received]
PHST- 2020/08/20 00:00 [accepted]
PHST- 2020/10/26 05:21 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2020/10/27 06:01 [medline]
PHST- 2020/09/25 00:00 [pmc-release]
AID - 10.3389/fneur.2020.573356 [doi]
PST - epublish
SO  - Front Neurol. 2020 Sep 25;11:573356. doi: 10.3389/fneur.2020.573356. eCollection 
      2020.