PMID- 33101543
OWN - NLM
STAT- MEDLINE
DCOM- 20210812
LR  - 20220417
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2020
DP  - 2020
TI  - Association of Estrogen Receptor 1 and Tumor Necrosis Factor alpha Polymorphisms with 
      Temporomandibular Joint Anterior Disc Displacement without Reduction.
PG  - 6351817
LID - 10.1155/2020/6351817 [doi]
LID - 6351817
AB  - OBJECTIVES: The aim of this study was to investigate the role of ESR1 rs1643821 
      and TNF-alpha rs1800629 as potential genetic factors regulating anterior disc 
      displacement without reduction-mediated inflammatory pathway. BACKGROUND: The 
      temporomandibular joint is a complex synovial joint that allows mandibular 
      movement in three directions. Although temporomandibular disorders are 
      widespread, limited data is available on the biochemical characteristics of the 
      displaced disc and quality of the surrounding soft tissue. Changes in 
      degenerative tissue provoke disc displacement which involves secretion of 
      inflammatory markers and sequential conversion of fibroblast-like cells into 
      chondrocyte-like cells. Due to the high occurrence in female adolescents, the 
      potential role of sex hormones in temporomandibular joint disorders has been 
      speculated. Furthermore, anterior disc displacement without reduction severely 
      affects the quality of life. METHODS: 124 Caucasian patients with a history of at 
      least one anterior disc displacement without reduction within 3 months were 
      enrolled. Anterior disc displacement without reduction was diagnosed based on 
      clinical examination, diagnostic criteria (DC)/TMD, and cone-beam computed 
      tomography/magnetic resonance imaging (CBCT/MRI). The control group consisted of 
      126 patients with no temporomandibular joint disorders. Genotyping of two single 
      nucleotide polymorphisms, estrogen receptor 1 (ESR1) rs1643821, and tumor 
      necrosis factor alpha (TNF-alpha) rs1800629 was performed. RESULTS: ESR1 rs1643821 showed 
      significant P values (using chi-square analysis) revealing the difference in 
      anterior disc displacement without reduction frequencies while TNF-alpha rs1800629 
      polymorphism was found to be statistically insignificant when compared to the 
      control group. Furthermore, patients with a genotype of ESR1 rs1643821 showed a 
      decreased probability (OR = 0.412) against anterior disc displacement without 
      reduction when compared to the GG genotype (OR = 1). CONCLUSION: ESR1 rs1643821 
      with A allele frequency was lower in patients with anterior disc displacement 
      without reduction compared to the control group. Thus, the rs1643821 variant is 
      significantly associated with susceptibility to the anterior disc displacement 
      without a reduction in European Caucasians. Conversely, TNF-alpha rs1800629 was a 
      statistically insignificant factor against anterior disc displacement without 
      reduction when compared to the control group.
CI  - Copyright (c) 2020 Bartosz Dalewski et al.
FAU - Dalewski, Bartosz
AU  - Dalewski B
AD  - Department of Dental Prosthetics, Pomeranian Medical University, Szczecin, 
      Poland.
FAU - Kaminska, Agata
AU  - Kaminska A
AUID- ORCID: 0000-0003-3944-7371
AD  - Department of Dental Prosthetics, Pomeranian Medical University, Szczecin, 
      Poland.
FAU - Bialkowska, Katarzyna
AU  - Bialkowska K
AD  - Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, 
      Poland.
FAU - Jakubowska, Anna
AU  - Jakubowska A
AD  - Department of Genetics and Pathology; and Independent Laboratory of Molecular 
      Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland.
FAU - Sobolewska, Ewa
AU  - Sobolewska E
AD  - Department of Dental Prosthetics, Pomeranian Medical University, Szczecin, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20201012
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Joint Dislocations/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Temporomandibular Joint Disc/physiopathology
MH  - Temporomandibular Joint Disorders/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
PMC - PMC7576356
COIS- The authors declare no conflicts of interest.
EDAT- 2020/10/27 06:00
MHDA- 2021/08/13 06:00
PMCR- 2020/10/12
CRDT- 2020/10/26 05:23
PHST- 2019/11/25 00:00 [received]
PHST- 2020/09/02 00:00 [revised]
PHST- 2020/09/22 00:00 [accepted]
PHST- 2020/10/26 05:23 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2021/08/13 06:00 [medline]
PHST- 2020/10/12 00:00 [pmc-release]
AID - 10.1155/2020/6351817 [doi]
PST - epublish
SO  - Dis Markers. 2020 Oct 12;2020:6351817. doi: 10.1155/2020/6351817. eCollection 
      2020.