PMID- 33101589
OWN - NLM
STAT- MEDLINE
DCOM- 20210513
LR  - 20240329
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2020
DP  - 2020
TI  - Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A 
      Case-Control Study.
PG  - 5471316
LID - 10.1155/2020/5471316 [doi]
LID - 5471316
AB  - BACKGROUND: Elevated oxidative stress status has been reported among pregnant 
      women with gestational diabetes mellitus (GDM). In diabetic condition, glucose 
      and lipid peroxidation, and alteration in antioxidant defense lead to increased 
      free radicals. The objective of this study was to investigate the association 
      between dietary total antioxidant capacity (DTAC) and GDM. METHODS: This 
      hospital-based case-control study was conducted in 463 pregnant women (healthy, n 
      = 263; GDM, n = 200). Anthropometric indices, blood pressure, and biochemical 
      analyses were measured. Dietary intake was assessed by the average of three 
      24-hour dietary intake records. DTAC was calculated by three indices: ferric 
      reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter 
      (TRAP), and Trolox equivalent antioxidant capacity (TEAC). Multivariable logistic 
      regression was performed to examine the relationship between DTAC and GDM risk in 
      crude and adjusted models. RESULTS: The mean age and BMI were 28.33 +/- 6.23 years 
      and 29.67 +/- 4.73 kg/m(2), respectively. Total energy, protein, and selenium 
      intakes were significantly higher in cases than controls (P < 0.05). Moreover, 
      intakes of carbohydrate, vitamins C, B6, and A, manganese, fruits, fruit juices, 
      vegetables, legumes, and FRAP were significantly lower in cases than controls (P 
      < 0.05). The risk of gestational diabetes mellitus was 85% lower among those in 
      the highest tertile of FRAP (OR: 0.15; 95% CI: 0.08-0.29). There was no 
      significant association between the risk of GDM and TRAP (OR: 1.62; 95% CI: 
      0.94-2.79) as well as TEAC (OR: 1.56; 95% CI: 0.89-2.72). CONCLUSION: Pregnant 
      women who were in the highest tertile of FRAP were at lower risk of GDM. However, 
      larger prospective studies are needed to confirm our findings.
CI  - Copyright (c) 2020 Elnaz Daneshzad et al.
FAU - Daneshzad, Elnaz
AU  - Daneshzad E
AD  - Department of Community Nutrition, School of Nutritional Science and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tehrani, Hatav
AU  - Tehrani H
AD  - Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Bellissimo, Nick
AU  - Bellissimo N
AD  - School of Nutrition, Ryerson University, Toronto, Canada.
FAU - Azadbakht, Leila
AU  - Azadbakht L
AUID- ORCID: 0000-0002-7169-6960
AD  - Department of Community Nutrition, School of Nutritional Science and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Department of Community Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Science, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
RN  - 0 (hemoglobin A1c protein, human)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Antioxidants/administration & dosage/*chemistry
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Diabetes, Gestational/*pathology
MH  - *Diet
MH  - Energy Intake
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Logistic Models
MH  - Odds Ratio
MH  - Pregnancy
MH  - Selenium/analysis
MH  - Triglycerides/analysis
MH  - Young Adult
PMC - PMC7568138
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/27 06:00
MHDA- 2021/05/14 06:00
PMCR- 2020/10/08
CRDT- 2020/10/26 05:23
PHST- 2020/04/22 00:00 [received]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/10/26 05:23 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2021/05/14 06:00 [medline]
PHST- 2020/10/08 00:00 [pmc-release]
AID - 10.1155/2020/5471316 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2020 Oct 8;2020:5471316. doi: 10.1155/2020/5471316. 
      eCollection 2020.