PMID- 33105353
OWN - NLM
STAT- MEDLINE
DCOM- 20210405
LR  - 20230912
IS  - 1533-4287 (Electronic)
IS  - 1064-8011 (Linking)
VI  - 34
IP  - 11
DP  - 2020 Nov
TI  - Effect of beta-Alanine Supplementation on Monocyte Recruitment and Cognition During 
      a 24-Hour Simulated Military Operation.
PG  - 3042-3054
LID - 10.1519/JSC.0000000000003809 [doi]
AB  - Wells, AJ, Varanoske, AN, Coker, NA, Kozlowski, GJ, Frosti, CL, Boffey, D, Harat, 
      I, Jahani, S, Gepner, Y, and Hoffman, JR. Effect of beta-alanine supplementation on 
      monocyte recruitment and cognition during a 24-hour simulated military operation. 
      J Strength Cond Res 34(11): 3042-3054, 2020-Sustained military operations 
      (SUSOPs) result in psychological stress and cognitive dysfunction, which may be 
      related to the recruitment of classical monocytes into the brain. This study 
      examined the effect of beta-alanine (BA) on cognition and monocyte recruitment 
      during a simulated 24-hour SUSOP. Nineteen healthy men ingested 12-g/d BA or 
      placebo for 14 days before an SUSOP. Monocyte chemoattractant protein-1 (MCP-1), 
      C-C chemokine receptor-2 (CCR2), and macrophage-1-antigen (CD11b) expression were 
      assessed through multiplex assay and flow cytometry. Psychological stress and 
      cognition were assessed through Automated Neuropsychological Assessment Metrics 
      (ANAM). A composite measure of cognition (COGcomp) was generated from throughput 
      scores extracted from 7 ANAM cognitive tests. Assessments occurred at baseline 
      (0H), 12 hours (12H), 18 hours (18H), and 24 hours (24H). Significance was 
      accepted at p </= 0.05. No significant effect of BA was noted for any variable (p's 
      > 0.05). The frequency and severity of symptoms of psychological stress increased 
      significantly at 18 and 24H compared with 0 and 12H (p's < 0.05). COGcomp 
      decreased significantly at 18 and 24H compared with 0 and 12H (p's </= 0.001). 
      MCP-1 peaked at 18H was significantly lower at 24H compared with 18H but remained 
      elevated at 24H compared with 0H (p's < 0.001). CCR2 expression was significantly 
      lower at 12 (p = 0.031), 18, and 24H (p's < 0.001). CD11b expression was 
      significantly higher at 12H (p = 0.039) and 24H (p's = 0.003). MCP-1 was 
      negatively associated with COGcomp (beta = -0.395, p = 0.002, r2 = 0.174). Neither 
      CCR2 or CD11b was related to COGcomp (p's > 0.05). Cognitive dysfunction during 
      SUSOPs is related to serum concentrations of MCP-1 but is not influenced by BA 
      supplementation.
FAU - Wells, Adam J
AU  - Wells AJ
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Varanoske, Alyssa N
AU  - Varanoske AN
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Coker, Nicholas A
AU  - Coker NA
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Kozlowski, Gregory J
AU  - Kozlowski GJ
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Frosti, Cheyanne L
AU  - Frosti CL
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Boffey, David
AU  - Boffey D
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Harat, Idan
AU  - Harat I
AD  - Institute of Exercise Physiology & Rehabilitation Science, College of Health 
      Professions and Sciences, University of Central Florida, Orlando, Florida.
FAU - Jahani, Shiva
AU  - Jahani S
AD  - Accreditation, Assessment and Analytics, College of Community Innovation and 
      Education, University of Central Florida, Orlando, Florida.
FAU - Gepner, Yftach
AU  - Gepner Y
AD  - Department of Epidemiology and Preventive Medicine, School of Public Health, 
      Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv 
      University, Tel-Aviv, Israel; and.
FAU - Hoffman, Jay R
AU  - Hoffman JR
AD  - Department of Molecular Biology, Ariel University, Ariel, Israel.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Strength Cond Res
JT  - Journal of strength and conditioning research
JID - 9415084
RN  - 0 (Chemokine CCL2)
RN  - 0 (Macrophage-1 Antigen)
RN  - 0 (Receptors, CCR2)
RN  - 11P2JDE17B (beta-Alanine)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/biosynthesis
MH  - Cognition/*drug effects
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Humans
MH  - Macrophage-1 Antigen/biosynthesis
MH  - Male
MH  - *Military Personnel
MH  - Monocytes/*drug effects/immunology
MH  - Receptors, CCR2/biosynthesis
MH  - Simulation Training/methods
MH  - Stress, Psychological/epidemiology/*physiopathology
MH  - Young Adult
MH  - beta-Alanine/*pharmacology
EDAT- 2020/10/27 06:00
MHDA- 2021/04/07 06:00
CRDT- 2020/10/26 20:17
PHST- 2020/10/26 20:17 [entrez]
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
AID - 00124278-202011000-00005 [pii]
AID - 10.1519/JSC.0000000000003809 [doi]
PST - ppublish
SO  - J Strength Cond Res. 2020 Nov;34(11):3042-3054. doi: 
      10.1519/JSC.0000000000003809.