PMID- 33105404
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20220316
IS  - 1536-5948 (Electronic)
IS  - 1076-2752 (Print)
IS  - 1076-2752 (Linking)
VI  - 62
IP  - 12
DP  - 2020 Dec
TI  - Per- and Polyfluoroalkyl Substance and Cardio Metabolic Markers in Firefighters.
PG  - 1076-1081
LID - 10.1097/JOM.0000000000002062 [doi]
AB  - OBJECTIVE: To evaluate if serum polyfluoroalkyl substances (PFAS) were associated 
      with cardiometabolic markers. METHODS: Serum PFAS were evaluated in 38 Arizona 
      firefighters and 49 participants from the 2009 to 2010 National Health and 
      Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid 
      intima-medial thickness (CIMT) were measured in the firefighters. RESULTS: 
      Firefighters had elevated perfluorohexane sulfonic acid (PFHxS) and lower 
      perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to 
      NHANES participants; for nine of the other 12 PFAS the values were not 
      significantly different. There were significant negative associations among 
      firefighters between perfluorodecanoic acid (PFDeA) and total cholesterol and 
      PFUA and interleukin-6. PFAS concentrations were not associated with CIMT. 
      CONCLUSION: PFHxS levels were elevated in firefighters compared to NHANES 
      subjects. Serum PFAS concentrations were not associated with increased 
      cardiometabolic risk measures in this population of firefighters.
FAU - Khalil, Naila
AU  - Khalil N
AD  - Department of Population and Public Health Sciences, Boonshoft School of 
      Medicine, Wright State University, Dayton, Ohio (Dr Khalil), School of Public 
      Health, and School of Medicine, West Virginia University, Morgantown, West 
      Virginia (Dr Ducatman), UA Health Sciences & Bio5 Institute, Statistics 
      Consulting Laboratory, University of Arizona, Tucson, Arizona (Mr Sinari, Dr 
      Billheimer), Epidemiology and Biostatistics Department, University of Arizona, 
      Tucson, Arizona (Dr Hu), Department of Community, Environment and Policy, Mel and 
      Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona 
      (Ms Littau, Dr Burgess).
FAU - Ducatman, Alan M
AU  - Ducatman AM
FAU - Sinari, Shripad
AU  - Sinari S
FAU - Billheimer, Dean
AU  - Billheimer D
FAU - Hu, Chengcheng
AU  - Hu C
FAU - Littau, Sally
AU  - Littau S
FAU - Burgess, Jefferey L
AU  - Burgess JL
LA  - eng
GR  - P30 ES006694/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Occup Environ Med
JT  - Journal of occupational and environmental medicine
JID - 9504688
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Biomarkers
MH  - *Environmental Pollutants
MH  - *Firefighters
MH  - *Fluorocarbons
MH  - Humans
MH  - Nutrition Surveys
MH  - Sulfonic Acids
PMC - PMC8906257
MID - NIHMS1785317
COIS- Conflict of Interest: none declared
EDAT- 2020/10/27 06:00
MHDA- 2021/08/19 06:00
PMCR- 2022/03/09
CRDT- 2020/10/26 20:18
PHST- 2020/10/27 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/10/26 20:18 [entrez]
PHST- 2022/03/09 00:00 [pmc-release]
AID - 00043764-202012000-00016 [pii]
AID - 10.1097/JOM.0000000000002062 [doi]
PST - ppublish
SO  - J Occup Environ Med. 2020 Dec;62(12):1076-1081. doi: 
      10.1097/JOM.0000000000002062.